ADARB1 and MIR206

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		ADARB1	MIR206
Description		adenosine deaminase RNA specific B1	microRNA 206
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	RISC Complex
	Molecular Function	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	MRNA 3'-UTR Binding Protein Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cholesterol Efflux Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Formation
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)
Interacting Genes		63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346	78 interacting genes: ADARB1 AIMP1 AQR C1QBP CELF1 CPSF1 CSTF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LCORL LIN28A LIN28B LRPPRC MARS1 MATR3 NOL4L NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		104	406989
HPRD ID		06777
Ensembl ID		ENSG00000197381	ENSG00000207604
Uniprot IDs		A0A994J4V7 A0A994J7T5 P78563
PDB IDs		1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K
Enriched GO Terms of Interacting Partners?		RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Gene Expression Nucleolus Positive Regulation Of Cytoplasmic Translation Regulation Of Macromolecule Biosynthetic Process Ligase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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