ADARB1 and EDIL3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ADARB1	EDIL3
Description		adenosine deaminase RNA specific B1	EGF like and discoidin domains 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity MRNA Binding Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Metal Ion Binding
	Biological Process	Immune System Process Adenosine To Inosine Editing RNA Processing MRNA Processing Neuromuscular Synaptic Transmission Negative Regulation Of Cell Population Proliferation Base Conversion Or Substitution Editing Facial Nerve Morphogenesis Hypoglossal Nerve Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Cell Migration Multicellular Organism Growth Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Neuromuscular Process Controlling Posture Defense Response To Virus Regulation Of Cell Cycle Innervation Muscle Tissue Morphogenesis Motor Behavior Motor Neuron Apoptotic Process	Cell Adhesion Positive Regulation Of Cell-substrate Adhesion
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Body mass index ( 25673413 28892062) Gastroesophageal reflux disease ( 34187846) HDL cholesterol levels ( 32203549) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mild obesity-related type 2 diabetes ( 34737425) Pulmonary function ( 17903307) Triglyceride levels ( 32203549) Type 2 diabetes ( 30130595)	Alzheimer's disease biomarkers ( 23419831) Ankylosing spondylitis ( 22138694) Anxiety and stress-related disorders ( 31116379) Asthma and hay fever ( 24388013) Blood trace element (Cu levels) ( 23720494) Chemerin levels ( 20237162) Loneliness ( 27629369) Mitochondrial DNA levels ( 25240745) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1/FVC ratio ( 26634245) Uterine fibroid size (maximum dimension) ( 30196971)
Interacting Genes		63 interacting genes: APP DCN EDIL3 EHHADH EIF2AK2 LARP6 MIR1-1 MIR1-2 MIR106A MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR199A2 MIR19B2 MIR200A MIR200B MIR206 MIR221 MIR222 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F1 MIRLET7F2 MIRLET7G NKRF NVL PIN1 PNPT1 PRKRA RBFOX2 RSL1D1 SNRNP70 STAU1 STOX1 STRBP SURF6 TARBP2 TCEANC UBE2I USP7 ZMAT4 ZNF346	4 interacting genes: ADARB1 ITGAV RBM11 RSPH1
Entrez ID		104	10085
HPRD ID		06777	09350
Ensembl ID		ENSG00000197381	ENSG00000164176
Uniprot IDs		A0A994J4V7 A0A994J7T5 P78563	O43854
PDB IDs		1ZY7 5ED1 5ED2 5HP2 5HP3 6D06 6VFF 7KFN 8E0F 8E4X 9D5J 9D5K	4D90
Enriched GO Terms of Interacting Partners?		RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Vesicle Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Cell Motility Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration	Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Hypoglossal Nerve Morphogenesis Adenosine To Inosine Editing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Entry Into Host Cell By A Symbiont-containing Vacuole Apolipoprotein A-I-mediated Signaling Pathway Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Blood Vessel Development C-X3-C Chemokine Binding Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Opsonin Binding Neuregulin Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Integrin Alphav-beta8 Complex Extracellular Matrix Protein Binding Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification Muscle Cell Fate Determination Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Glomerulus Morphogenesis Regulation Of Synaptic Activity Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Sinoatrial Valve Morphogenesis AMPA Selective Glutamate Receptor Signaling Pathway Radial Spoke Head 1 Radial Spoke Head 3 Radial Spoke Head Ribbon Synapse Photoreceptor Distal Connecting Cilium TRNA-specific Adenosine Deaminase Activity NMDA Selective Glutamate Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Ciliary Transition Zone Adenosine Deaminase Activity Regulation Of Entry Of Bacterium Into Host Cell Transforming Growth Factor Beta Production Positive Regulation Of Behavioral Fear Response Post-chaperonin Tubulin Folding Pathway Outer Dense Fiber Deaminase Activity Positive Regulation Of Fear Response
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