ANAPC10 and LRP2

Number of citations of the paper that reports this interaction (PubMedID 10827173)
0

Data Source:
BioGRID (two hybrid)

		ANAPC10	LRP2
Description		anaphase promoting complex subunit 10	LDL receptor related protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Brush Border Clathrin-coated Pit External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Brush Border Membrane Endosome Lumen Cell Projection Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Cargo Receptor Activity Hormone Binding Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Nervous System Development Heart Development Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Gene Expression Protein Transport Cobalamin Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Diol Metabolic Process Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Vitamin Transport Vagina Development Coronary Vasculature Development Coronary Artery Morphogenesis Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Cranial Skeletal System Development Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport Transport of RCbl within the body
Drugs			Urokinase Insulin human
Diseases			Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Height ( 25429064 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 29779033 31451708 31152163 31015462 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Gout ( 33832965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29403010 29124443) Urate levels ( 20139978 31578528)
Interacting Genes		16 interacting genes: ANAPC11 ANAPC7 CDC16 CDC20 CDC23 CDC27 LIG4 LRP1 LRP2 LRP8 MAPK8IP2 NLRP3 PTEN SMAD2 SMAD3 TSC22D2	53 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 DYRK1A GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR USP40
Entrez ID		10393	4036
HPRD ID		16488	02509
Ensembl ID		ENSG00000164162	ENSG00000081479
Uniprot IDs		D6RD74 Q9UM13	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		1JHJ 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2M0P
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Branched Polyubiquitination Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Positive Regulation Of Chromosome Separation Protein K11-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Nuclear Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Positive Regulation Of Cellular Component Organization Regulation Of Reproductive Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Catabolic Process Protein K48-linked Ubiquitination Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Nuclear Division Cell Division Regulation Of Cellular Component Organization Positive Regulation Of Mitotic Cell Cycle Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Low-density Lipoprotein Particle Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Macromolecule Catabolic Process Cargo Receptor Activity Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Paraxial Mesoderm Morphogenesis Positive Regulation Of Cell Cycle Process Proteolysis Protein Polyubiquitination Positive Regulation Of Lysosomal Protein Catabolic Process Mesoderm Morphogenesis Positive Regulation Of Cell Cycle Protein Ubiquitination	Low-density Lipoprotein Particle Receptor Binding Regulation Of Endocytosis Heparin Binding Regulation Of Cell-substrate Adhesion Very-low-density Lipoprotein Particle Regulation Of Receptor-mediated Endocytosis Amyloid-beta Binding Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Biological Quality Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Vesicle-mediated Transport Protein Kinase Binding Negative Regulation Of Fibrinolysis Regulation Of Locomotion Establishment Or Maintenance Of Cell Polarity Signal Transduction Chylomicron Regulation Of Cell Migration Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Component Organization Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Cell Projection Organization Receptor Ligand Activity Intermediate-density Lipoprotein Particle Regulation Of Endothelial Cell Migration Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Signaling Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Fibrinolysis Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Extracellular Exosome Positive Regulation Of Cell Motility Positive Regulation Of Transport Regulation Of Amyloid-beta Clearance Regulation Of Proteolysis Extracellular Region Regulation Of Transport Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Locomotion Positive Regulation Of Cellular Component Organization Endosome Lumen Cell Periphery Cell Adhesion Positive Regulation Of Receptor-mediated Endocytosis
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