NOD1 and CASP1

Number of citations of the paper that reports this interaction (PubMedID 12459189)
0

Data Source:
HPRD (in vivo, in vitro)

		NOD1	CASP1
Description		nucleotide binding oligomerization domain containing 1	caspase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle	Nucleolus Cytoplasm Cytosol Microtubule Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex Protease Inhibitor Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Ubiquitin Binding Protein-containing Complex Binding CARD Domain Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Enzyme Binding Kinase Binding Cytokine Binding Identical Protein Binding CARD Domain Binding
	Biological Process	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Autophagy Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Xenophagy Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Xenophagy	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Pattern Recognition Receptor Signaling Pathway Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Protein Autoprocessing Protein Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Icosanoid Biosynthetic Process Ceramide Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Maturation Defense Response To Virus Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cytokine Precursor Processing Signaling Receptor Ligand Precursor Processing AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	NOD1/2 Signaling Pathway Interleukin-1 processing Pyroptosis TP53 Regulates Transcription of Caspase Activators and Caspases The NLRP3 inflammasome The AIM2 inflammasome The IPAF inflammasome Interleukin-37 signaling Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs			Acetylsalicylic acid Minocycline Pralnacasan LAX-101 Emricasan VX-765 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Z-Val-Ala-Asp fluoromethyl ketone 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		15 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 CFTR GABRB1 IRGM NLRP1 RIPK2 RNF34 SOX8 XIAP	46 interacting genes: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17P CARD8 CASP10 CASP14 CASP8 CAST CDK11B CFTR EGFR FGF2 GSDMD HTT HUWE1 IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARP1 PLA2G4A PLA2G4B PRKN PSEN1 PSEN2 PYCARD RIPK2 RNF31 SERPINB9 TFAP2A TIRAP VAC14
Entrez ID		10392	834
HPRD ID		05815	00977
Ensembl ID		ENSG00000106100	ENSG00000137752
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239	A8K249 A8K257 P29466
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7 5FNA 5MMV 5MTK 6BZ9 6F6R 6KN0 6PZP 6VIE 7KEU 8SV1 8WRA
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Defense Response Cysteine-type Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway NLRP1 Inflammasome Complex Activation Of Innate Immune Response Regulation Of Innate Immune Response Pyroptotic Inflammatory Response Cysteine-type Peptidase Activity Response To Lipid Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Defense Response To Bacterium Response To Lipopolysaccharide Regulation Of Defense Response Positive Regulation Of Innate Immune Response Protein Maturation Canonical Inflammasome Complex Response To Molecule Of Bacterial Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Pyroptotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Stress Protein Processing Positive Regulation Of Interleukin-1 Production Response To Bacterium C-terminal Protein Lipidation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response Execution Phase Of Apoptosis Peptidase Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteolysis Protein Metabolic Process Regulation Of Interleukin-1 Production	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Programmed Cell Death Cell Death Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Regulation Of Interleukin-1 Beta Production Regulation Of Multicellular Organismal Process Regulation Of Defense Response Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Inflammatory Response Regulation Of Interleukin-1 Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Cytokine Production Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Apoptotic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Defense Response Positive Regulation Of Interleukin-1 Production Defense Response To Bacterium Identical Protein Binding Negative Regulation Of Apoptotic Signaling Pathway Cytosol Protein-containing Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Innate Immune Response Response To Lipid Regulation Of Immune System Process Canonical Inflammasome Complex Intracellular Signal Transduction
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