NOD1 and CASP4

Number of citations of the paper that reports this interaction (PubMedID 10329646)
0

Data Source:
HPRD (in vivo)

		NOD1	CASP4
Description		nucleotide binding oligomerization domain containing 1	caspase 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Ubiquitin Binding Protein-containing Complex Binding CARD Domain Binding	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding
	Biological Process	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Autophagy Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Xenophagy Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Xenophagy	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage
Drugs			Incadronic acid
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Major depressive disorder ( 29317602)
Interacting Genes		15 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 CFTR GABRB1 IRGM NLRP1 RIPK2 RNF34 SOX8 XIAP	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		10392	837
HPRD ID		05815	04047
Ensembl ID		ENSG00000106100	ENSG00000196954
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239	P49662
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW	6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Defense Response Cysteine-type Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway NLRP1 Inflammasome Complex Activation Of Innate Immune Response Regulation Of Innate Immune Response Pyroptotic Inflammatory Response Cysteine-type Peptidase Activity Response To Lipid Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Defense Response To Bacterium Response To Lipopolysaccharide Regulation Of Defense Response Positive Regulation Of Innate Immune Response Protein Maturation Canonical Inflammasome Complex Response To Molecule Of Bacterial Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Pyroptotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Stress Protein Processing Positive Regulation Of Interleukin-1 Production Response To Bacterium C-terminal Protein Lipidation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response Execution Phase Of Apoptosis Peptidase Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteolysis Protein Metabolic Process Regulation Of Interleukin-1 Production	Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?