NOD1 and CARD6

Number of citations of the paper that reports this interaction (PubMedID 12775719)
0

Data Source:
HPRD (in vitro)

		NOD1	CARD6
Description		nucleotide binding oligomerization domain containing 1	caspase recruitment domain family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Ubiquitin Binding Protein-containing Complex Binding CARD Domain Binding	Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Autophagy Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Xenophagy Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Xenophagy	Apoptotic Process Regulation Of Apoptotic Process
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Multiple system atrophy ( 27629089) Psoriasis ( 25939698)
Interacting Genes		15 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 CFTR GABRB1 IRGM NLRP1 RIPK2 RNF34 SOX8 XIAP	2 interacting genes: NOD1 RIPK2
Entrez ID		10392	84674
HPRD ID		05815	09871
Ensembl ID		ENSG00000106100	ENSG00000132357
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239	Q9BX69
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Defense Response Cysteine-type Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway NLRP1 Inflammasome Complex Activation Of Innate Immune Response Regulation Of Innate Immune Response Pyroptotic Inflammatory Response Cysteine-type Peptidase Activity Response To Lipid Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Defense Response To Bacterium Response To Lipopolysaccharide Regulation Of Defense Response Positive Regulation Of Innate Immune Response Protein Maturation Canonical Inflammasome Complex Response To Molecule Of Bacterial Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Pyroptotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Stress Protein Processing Positive Regulation Of Interleukin-1 Production Response To Bacterium C-terminal Protein Lipidation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response Execution Phase Of Apoptosis Peptidase Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteolysis Protein Metabolic Process Regulation Of Interleukin-1 Production	Positive Regulation Of Xenophagy Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Xenophagy Cellular Response To Muramyl Dipeptide CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Response To Muramyl Dipeptide Positive Regulation Of Macrophage Cytokine Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of Macrophage Cytokine Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Stress-activated Protein Kinase Signaling Cascade ERK1 And ERK2 Cascade JNK Cascade Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Macroautophagy Regulation Of Interleukin-1 Beta Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Regulation Of Cytokine Production Involved In Immune Response Regulation Of JNK Cascade Regulation Of Interleukin-6 Production Macroautophagy Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy Innate Immune Response-activating Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Macroautophagy Regulation Of Production Of Molecular Mediator Of Immune Response Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway MAPK Cascade Positive Regulation Of Immune Effector Process Regulation Of ERK1 And ERK2 Cascade Autophagy Defense Response To Bacterium Positive Regulation Of Innate Immune Response Response To Interleukin-18
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