NOD1 and NLRP1

Number of citations of the paper that reports this interaction (PMID 11113115)
32

Data Source:
HPRD (in vitro)

		NOD1	NLRP1
Gene Name		nucleotide-binding oligomerization domain containing 1	NLR family, pyrin domain containing 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane	Intracellular Nucleus Cytosol NLRP1 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding CARD Domain Binding	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Muramyl Dipeptide Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP	9 interactors: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD
Entrez ID		10392	22861
HPRD ID		05815	07364
Ensembl ID		ENSG00000106100	ENSG00000091592
Uniprot IDs		Q9Y239	E9PE50 Q9C000 Q9H5Z7
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M	1PN5 3KAT 4IFP
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Response To Bacterium Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Proteolysis Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Cobalt Ion Response To Other Organism Response To Molecule Of Bacterial Origin Apoptotic Signaling Pathway Response To Biotic Stimulus Signaling Cell Communication Innate Immune Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Secretion Response To Organic Cyclic Compound Proteolysis Positive Regulation Of Interleukin-1 Secretion	Apoptotic Process Programmed Cell Death Cell Death Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Secretion Regulation Of Proteolysis Positive Regulation Of Signal Transduction Regulation Of Autophagy Response To Other Organism Regulation Of Interleukin-1 Beta Secretion Innate Immune Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Pyroptosis Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process
Tagcloud ?		bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric oligomerization p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall	ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Difference) ?		bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric oligomerization p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall	ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5
Tagcloud (Intersection) ?