NOD1 and CASP2

Number of citations of the paper that reports this interaction (PMID 10329646)
113

Data Source:
HPRD (in vivo)

		NOD1	CASP2
Gene Name		nucleotide-binding oligomerization domain containing 1	caspase 2, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane	Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding CARD Domain Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway p75 NTR receptor-mediated signalling NADE modulates death signalling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP	30 interactors: ADCYAP1 BID BIRC2 CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		10392	835
HPRD ID		05815	02800
Ensembl ID		ENSG00000106100	ENSG00000106144
Uniprot IDs		Q9Y239	C9JRR9 D3DXD8 D3DXD9 P42575
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M	1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Response To Bacterium Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Proteolysis Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Cobalt Ion Response To Other Organism Response To Molecule Of Bacterial Origin Apoptotic Signaling Pathway Response To Biotic Stimulus Signaling Cell Communication Innate Immune Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Secretion Response To Organic Cyclic Compound Proteolysis Positive Regulation Of Interleukin-1 Secretion	Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Response To Stress Signaling Positive Regulation Of Catalytic Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Signal Transduction Viral Process Cell Communication Positive Regulation Of Hydrolase Activity Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Execution Phase Of Apoptosis Positive Regulation Of Cell Death Response To Stimulus Glial Cell Apoptotic Process Protein Metabolic Process Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?		bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric oligomerization p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall	amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Difference) ?		bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric oligomerization p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall	amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Intersection) ?