DLST and OGDH

Number of citations of the paper that reports this interaction (PMID 9727038)
6

Data Source:
HPRD (in vitro)

		DLST	OGDH
Gene Name		dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Thiamine Pyrophosphate Binding Heat Shock Protein Binding Oxoglutarate Dehydrogenase (NAD+) Activity Metal Ion Binding Chaperone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process NADH Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Olfactory Bulb Mitral Cell Layer Development
Pathways		Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)	Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs			NADH Valproic Acid
Diseases
GWAS		Non-small cell lung cancer ( 23144319)
Protein-Protein Interactions		15 interactors: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1	3 interactors: DLD DLST PLSCR1
Entrez ID		1743	4967
HPRD ID		00520	08938
Ensembl ID		ENSG00000119689	ENSG00000105953
Uniprot IDs		B7Z6J1 P36957	B4E3E9 E9PCR7 E9PDF2 E9PFG7 Q02218
PDB IDs			3ERY
Enriched GO Terms of Interacting Partners?			Lysine Catabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Cellular Amino Acid Catabolic Process Cellular Respiration Carboxylic Acid Catabolic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Alpha-amino Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Phosphatidylserine Biosynthetic Process Generation Of Precursor Metabolites And Energy Cellular Amino Acid Metabolic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phospholipid Scrambling Detoxification Of Mercury Ion Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Sperm Capacitation Branched-chain Amino Acid Catabolic Process Response To Interferon-beta Acetyl-CoA Metabolic Process Response To Mercury Ion Phosphatidylserine Metabolic Process Positive Regulation Of ATPase Activity Regulation Of Mast Cell Activation Acute-phase Response Regulation Of ATPase Activity Mitochondrial Electron Transport, NADH To Ubiquinone Organophosphate Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Viral Genome Replication Organic Acid Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Acyl-CoA Metabolic Process Regulation Of Membrane Lipid Distribution Regulation Of Viral Genome Replication Oxidative Phosphorylation Negative Regulation Of Viral Process Acute Inflammatory Response Cellular Nitrogen Compound Metabolic Process Regulation Of Fatty Acid Metabolic Process Phospholipid Transport Oxidation-reduction Process Nitrogen Compound Metabolic Process Respiratory Electron Transport Chain Cell Redox Homeostasis Electron Transport Chain
Tagcloud ?		acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis	acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers
Tagcloud (Difference) ?		acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis	acp acyl amido biosynthetic catalyse catalyses gcv homologue lagged lds ligases lip3 lipl lipm lipoate lipoyl lpl lpla lpls octanoate octanoyl octanoyltransferase oxoglutarate pdh pyruvate salvaged subtilis surprising transfers
Tagcloud (Intersection) ?