DLST and OGDH

Number of citations of the paper that reports this interaction (PubMedID 9727038)
0

Data Source:
HPRD (in vitro)

		DLST	OGDH
Description		dihydrolipoamide S-succinyltransferase	oxoglutarate dehydrogenase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors Thiamine Pyrophosphate Binding Heat Shock Protein Binding Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process NAD+ Metabolic Process Cerebellar Cortex Development Striatum Development Hippocampus Development Thalamus Development Pyramidal Neuron Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Olfactory Bulb Mitral Cell Layer Development
Pathways		Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA	Glycine degradation Mitochondrial protein degradation OGDH complex synthesizes succinyl-CoA from 2-OG
Drugs			NADH Valproic acid Xanthinol
Diseases			Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Femur bone mineral density x serum urate levels interaction ( 34046847) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer in never smokers ( 28604730) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		21 interacting genes: ARIH2 CCDC86 DLG5 FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1	6 interacting genes: ANXA2 DLD DLST HSD17B10 PLSCR1 USP7
Entrez ID		1743	4967
HPRD ID		00520	08938
Ensembl ID		ENSG00000119689	ENSG00000105953
Uniprot IDs		B7Z6J1 P36957	A0A140VJQ5 B4DH65 B4E3E9 E9PCR7 E9PDF2 Q02218
PDB IDs		6H05	3ERY 7WGR 8I0K
Enriched GO Terms of Interacting Partners?			Oxoadipate Dehydrogenase Complex Oxoglutarate Dehydrogenase Complex Succinyl-CoA Metabolic Process Amino Acid Catabolic Process 2-oxoglutarate Metabolic Process Branched-chain Amino Acid Catabolic Process Branched-chain Amino Acid Metabolic Process Acetyl-CoA Metabolic Process Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Aspartate Family Amino Acid Metabolic Process Negative Regulation Of Endocytosis Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Dihydrolipoyllysine-residue Succinyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process Serine-type Endopeptidase Inhibitor Activity Acyl-CoA Metabolic Process Dicarboxylic Acid Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Succinyl-CoA Biosynthetic Process 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Lead Ion Binding Positive Regulation Of Platelet-derived Growth Factor Production Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Vesicle-mediated Transport Acrosomal Matrix L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface
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