DLST and FLII

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	FLII
Description		dihydrolipoamide S-succinyltransferase	FLII actin remodeling protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex	Podosome Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Brush Border Focal Adhesion Actin Cytoskeleton Centriolar Satellite Cell Projection Anchoring Junction
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Actin Polymerization Or Depolymerization Myofibril Assembly Sarcomere Organization Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		21 interacting genes: ARIH2 CCDC86 DLG5 FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1	15 interacting genes: ACTB ACTL6A CARM1 DLST ESR1 GRIP1 LCOR LRRFIP1 LRRFIP2 MYD88 NCOA2 OPTN PRMT1 RNF34 TRAIP
Entrez ID		1743	2314
HPRD ID		00520	02647
Ensembl ID		ENSG00000119689	ENSG00000177731
Uniprot IDs		B7Z6J1 P36957	Q13045
PDB IDs		6H05
Enriched GO Terms of Interacting Partners?			Regulation Of DNA-templated Transcription Nucleoplasm Nitric-oxide Synthase Regulator Activity Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Remodeling Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination Nucleus Intracellular Receptor Signaling Pathway Protein Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Brahma Complex Regulation Of Macromolecule Metabolic Process NpBAF Complex Regulation Of Double-strand Break Repair Via Homologous Recombination GBAF Complex Chromatin Organization RSC-type Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Double-strand Break Repair Regulation Of Gene Expression Positive Regulation Of Cell Population Proliferation Beta-catenin Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA Recombination Positive Regulation Of DNA Repair Signal Transduction NuA4 Histone Acetyltransferase Complex Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair SWI/SNF Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Methyltransferase Activity Protein-containing Complex Cellular Response To Estradiol Stimulus Negative Regulation Of Intracellular Signal Transduction Regulation Of G0 To G1 Transition Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Signal Transduction Nucleosomal DNA Binding
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