DLST and DLG5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	DLG5
Description		dihydrolipoamide S-succinyltransferase	discs large MAGUK scaffold protein 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Oxoglutarate Dehydrogenase Complex Oxoadipate Dehydrogenase Complex	Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Membrane Cell Junction Ciliary Basal Body Cell Projection Synapse Anchoring Junction Glutamatergic Synapse
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Epithelial To Mesenchymal Transition Establishment Or Maintenance Of Cell Polarity Signal Transduction Negative Regulation Of Cell Population Proliferation Tissue Development Positive Regulation Of Signal Transduction Glial Cell Differentiation Maintenance Of Cell Polarity Cell Differentiation Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Animal Organ Development Regulation Of Multicellular Organismal Process Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Neuroepithelial Cell Differentiation Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion Postsynapse Organization
Pathways		Glycine degradation OGDH complex synthesizes succinyl-CoA from 2-OG Protein lipoylation OADH complex synthesizes glutaryl-CoA from 2-OA	RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Depression ( 29700475) Eosinophil count ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		21 interacting genes: ARIH2 CCDC86 DLG5 FLII GRIK1 HUNK NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS USP7 WEE2-AS1 ZBTB16 ZHX1	8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		1743	9231
HPRD ID		00520	04972
Ensembl ID		ENSG00000119689	ENSG00000151208
Uniprot IDs		B7Z6J1 P36957	Q8TDM6
PDB IDs		6H05	1UIT
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein-containing Complex Assembly Focal Adhesion Positive Regulation Of Organelle Organization Cellular Response To Lipoprotein Particle Stimulus Basolateral Plasma Membrane Regulation Of Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Cholesterol Binding Sphingolipid Floppase Activity Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Dihydrolipoyllysine-residue Succinyltransferase Activity Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Telomere Maintenance Response To Vitamin B3 Regulation Of Cell Communication Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Intracellular Signal Transduction Apolipoprotein A-I Receptor Activity Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Myoblast Fusion Involved In Skeletal Muscle Regeneration Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Renal Inner Medulla Development Scrib-APC-beta-catenin Complex
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