NPM2 and NPM1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NPM2	NPM1
Gene Name		nucleophosmin/nucleoplasmin 2	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic Chromatin Nuclear Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome
	Molecular Function	Nucleic Acid Binding Chromatin Binding Enzyme Binding Histone Binding	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Exit From Mitosis Single Fertilization Embryo Development Oocyte Differentiation Positive Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Positive Regulation Of Meiotic Nuclear Division Protein Homooligomerization	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Pathways			Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: NPM1 NPM3 PLEKHF2 SDCBP2 SRPK2	53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1
Entrez ID		10361	4869
HPRD ID		12160	01246
Ensembl ID		ENSG00000158806	ENSG00000181163
Uniprot IDs		Q6NVH6 Q86SE8	P06748
PDB IDs		3T30	2LLH 2P1B 2VXD
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex Biogenesis Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Nuclear Speck Organization Ribonucleoprotein Complex Assembly Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Ribosome Biogenesis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Centriole Replication Negative Regulation Of Centrosome Duplication	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		autoantigenic chaperones dramatic egg embryogenesis evolutionarily evolutionary evolved fertilization genuine h2a h2b histones monophyletic nasp npm3 nucleoplasmin paternal plethora ptms recurrently reviews revolves somatic sperm storage takes taxa	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Difference) ?		autoantigenic chaperones dramatic egg embryogenesis evolutionarily evolutionary evolved fertilization genuine h2a h2b histones monophyletic nasp npm3 nucleoplasmin paternal plethora ptms recurrently reviews revolves somatic sperm storage takes taxa	aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Intersection) ?