ARHGEF16 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF16	LASP1
Description		Rho guanine nucleotide exchange factor 16	LIM and SH3 protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		11 interacting genes: AKT1 CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TAX1BP3 TFG YWHAQ	121 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX
Entrez ID		27237	3927
HPRD ID		12478	04229
Ensembl ID		ENSG00000130762	ENSG00000002834
Uniprot IDs		B3KTS4 Q5VV41	B4DIC4 Q14847
PDB IDs		1X6B	3I35
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Release Of Cytochrome C From Mitochondria Identical Protein Binding Regulation Of Protein Localization To Nucleus 14-3-3 Protein Binding Protein Localization To Nucleus Regulation Of Protein Localization To Cell Surface Negative Regulation Of Protein Localization Regulation Of Release Of Cytochrome C From Mitochondria Postsynapse Regulation Of TRNA Methylation Microtubule Plus End Polymerase	Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration
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