ARHGEF16

Description		Rho guanine nucleotide exchange factor 16
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GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding
	Biological Process	Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)
Novel Interacting Genes		1 novel interacting genes: TNFRSF18
Interacting Genes		11 interacting genes: AKT1 CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TAX1BP3 TFG YWHAQ
Entrez ID		27237
HPRD ID		12478
Ensembl ID		ENSG00000130762
Uniprot IDs		B3KTS4 Q5VV41
PDB IDs		1X6B
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Release Of Cytochrome C From Mitochondria Identical Protein Binding Regulation Of Protein Localization To Nucleus 14-3-3 Protein Binding Protein Localization To Nucleus Regulation Of Protein Localization To Cell Surface Negative Regulation Of Protein Localization Regulation Of Release Of Cytochrome C From Mitochondria Postsynapse Regulation Of TRNA Methylation Microtubule Plus End Polymerase
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