ARHGEF16

Gene Name		Rho guanine nucleotide exchange factor (GEF) 16
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Activation Of Rac GTPase Activity Activation Of Cdc42 GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-protein Interactions		4 interactors: LNX1 MAPK1IP1L TFG YWHAQ
Entrez ID		27237
HPRD ID		12478
Ensembl ID		ENSG00000130762
Uniprot IDs		B3KTS4 B4DJM7 Q5VV41
PDB IDs		1X6B
Enriched GO Terms of Interacting Partners?
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