MDFI and SPRED2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MDFI	SPRED2
Description		MyoD family inhibitor	sprouty related EVH1 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Identical Protein Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Maintenance Of Protein Location In Cell Negative Regulation Of DNA-templated Transcription Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation	Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases
GWAS		Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)	Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 33339817 29403010) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 27569725) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596 24390342 24782177 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)
Interacting Genes		405 interacting genes: AANAT AASDHPPT ABCF3 ABHD11 ABHD17A ADAMTSL3 ADRA2C AEBP2 AGXT AKAP17A ANKRD13C-DT AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ARMC7 ATG12 ATN1 ATOSB ATP5F1D ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAG3 BAHD1 BANP BBS2 BCAM BCL6 BCL6B BEX1 BEX2 BEX3 C10orf62 C1orf216 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBLL2 CBX2 CBX8 CC2D1B CCDC116 CCDC120 CCDC185 CCDC187 CCDC198 CCDC33 CCER1 CCNL2 CDC20B CDC37 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHP2 CHRNG CIMAP1B CLPB CNNM3 CRACR2A CREB5 CRH CRX CRY1 CSNK1G2-AS1 CSNK1G3 CTRC CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNAJB13 DNMT3A DNPEP DOCK2 DOK3 DUSP6 DYNLT4 EBI3 EFEMP2 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FADS6 FAM120AOS FAM124B FAM161A FAM161B FAM27E3 FAM90A1 FARS2 FASTK FBXL18 FBXO34 FBXW5 FES FEZF1 FNDC11 FOXD4 FOXD4L1 FOXD4L3 FOXD4L6 FZD9 GABRD GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNE GNG5 GPANK1 GPATCH2L GPRIN2 GREM1 GTF3C5 HAPLN2 HASPIN HEYL HHEX HNRNPLL HOXA1 HOXB9 HPCAL1 HTR1B HYPK IFRD2 ILF3 INTS11 IQUB ITGB4 JOSD1 KANSL1 KAT5 KCTD7 KIAA0040 KIAA0408 KIF1A KLHL38 KPNA2 KRAS KRT77 LAMB3 LASP1 LCE1A LCE1B LCE1D LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LIMS2 LIN7A LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGEC3 MAGED1 MAGEF1 MAPK1 MAPKBP1 MBD1 MBD3L2 MCM5 MEOX2 METTL17 MGAT5B MRPL20-AS1 MVP MXI1 MYF5 MYOD1 MYOG MYPOP NAB2 NDUFA7 NECTIN2 NEU4 NIBAN3 NKD1 NOL4L-DT NPDC1 NPEPL1 NR1H2 NR1H3 NSD1 NTAQ1 NUBP2 NUFIP2 ODAD4 ODAPH ODF1 OLIG3 OTX1 PARP11 PATZ1 PBXIP1 PCSK5 PDGFA PDGFB PDIA5 PDS5A PELI2 PGLS PHF1 PHLDA1 PIBF1 PID1 PIDD1 PIH1D2 PIN1 PKD2 PLEKHG4 POLL POM121L8P PRKAB2 PRPF18 PRPF31 PRR34 PTK7 PTPMT1 RABL6 RAC1 RASD1 REG3A REX1BD RFX2 RHOXF2 RIN1 RIPPLY1 RNF111 RNF6 RTP5 SAPCD2 SCAMP4 SCNM1 SELENOM SEMA3B SERF2 SFI1 SHFL SHMT1 SIX1 SLC13A5 SLC15A3 SLC25A10 SLC33A2 SLC35A2 SLC35D4 SLC9A1 SMYD1 SNX18 SOCS7 SPATA24 SPATA3 SPATA8 SPG7 SPMAP2 SPMIP2 SPON1 SPRED2 SPRY1 SPRY2 SUOX TACO1 TAP1 TASOR2 TBC1D3B TBC1D3G TCEANC TCF3 TEAD4 TEDC2 TGIF1 TH THAP7 TIE1 TINAGL1 TLE5 TMIE TNNI1 TNP2 TOR1A TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TSFM TSGA10IP TSPAN4 TSPYL1 TSPYL6 TTC23 TTLL10 TUSC2 TXN2 TYMSOS TYRO3 USP20 USP6 VASN VGLL3 VHL VPS72 VSTM4 WDFY3 WNT11 YPEL3 YY1 ZBBX ZBTB24 ZBTB25 ZBTB42 ZBTB9 ZC3HAV1 ZDHHC1 ZFYVE26 ZIM2 ZNF101 ZNF12 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF221 ZNF223 ZNF23 ZNF230 ZNF264 ZNF266 ZNF330 ZNF408 ZNF414 ZNF417 ZNF426 ZNF433 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF461 ZNF479 ZNF490 ZNF491 ZNF497 ZNF512B ZNF524 ZNF559 ZNF564 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF607 ZNF613 ZNF646 ZNF648 ZNF662 ZNF669 ZNF670 ZNF679 ZNF688 ZNF696 ZNF707 ZNF764 ZNF784 ZNF785 ZNF786 ZNF79 ZNF837 ZNF844 ZNHIT1	30 interacting genes: AQP1 CTSD DYRK1A KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837
Entrez ID		4188	200734
HPRD ID		07280	18100
Ensembl ID		ENSG00000112559	ENSG00000198369
Uniprot IDs		B1AKB6 Q99750	B3KPL5 Q7Z698
PDB IDs			2JP2 8EQ5
Enriched GO Terms of Interacting Partners?		Protein Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Metal Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratinization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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