MDFI and GDF15

Number of citations of the paper that reports this interaction (PMID 19060904)
157

Data Source:
BioGRID (two hybrid)

		MDFI	GDF15
Gene Name		MyoD family inhibitor	growth differentiation factor 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation	Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Development SMAD Protein Signal Transduction Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844	2 interactors: MAPK14 MDFI
Entrez ID		4188	9518
HPRD ID		07280	05608
Ensembl ID		ENSG00000112559	ENSG00000130513
Uniprot IDs		B1AKB6 Q99750	Q99988
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity P38MAPK Cascade Regulation Of Nucleocytoplasmic Transport MAPK Cascade Regulation Of Intracellular Protein Transport Activation Of Protein Kinase Activity Skeletal System Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Wnt Signaling Pathway Regulation Of Intracellular Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Brown Fat Cell Differentiation Skeletal System Development Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Regulation Of Protein Transport 3'-UTR-mediated MRNA Stabilization Regulation Of Establishment Of Protein Localization Stress-induced Premature Senescence Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Myoblast Differentiation Trophoblast Giant Cell Differentiation Positive Regulation Of Myoblast Fusion Positive Regulation Of Protein Modification Process Response To Muramyl Dipeptide Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Organ Morphogenesis Regulation Of Cellular Localization Cartilage Condensation
Tagcloud ?			a2780 a2780cis abrogated allowing alter appropriate basal bearing carboplatin colony comparing interestingly knockdown lobular microarrays necrotic ovarian p16 p27 parental platinum poorly resistance serve shrna suppressing transduced variant
Tagcloud (Difference) ?			a2780 a2780cis abrogated allowing alter appropriate basal bearing carboplatin colony comparing interestingly knockdown lobular microarrays necrotic ovarian p16 p27 parental platinum poorly resistance serve shrna suppressing transduced variant
Tagcloud (Intersection) ?