Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
MAPKBP1 and MAPK10
Number of citations of the paper that reports this interaction (PMID
10471813
)
3
Data Source:
HPRD
(two hybrid, in vitro)
MAPKBP1
MAPK10
Gene Name
mitogen-activated protein kinase binding protein 1
mitogen-activated protein kinase 10
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Molecular Function
JUN Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Biological Process
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
JNK Cascade
JUN Phosphorylation
Response To Light Stimulus
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Regulation Of Circadian Rhythm
Innate Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Oxidative Stress Induced Senescence
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One
Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
9-(4-Hydroxyphenyl)-2,7-Phenanthroline
Phosphoaminophosphonic Acid-Adenylate Ester
N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime
5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide
N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
N-{2\'-[(4-FLUOROPHENYL)AMINO]-4,4\'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE
2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide
1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE
Diseases
GWAS
Liver enzyme levels (alanine transaminase) (
22001757
)
Protein-Protein Interactions
31 interactors:
ADAMTSL4
ALG13
APTX
GLRX3
KEAP1
KRT31
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-2
KRTAP4-12
KRTAP5-9
KRTAP9-2
KRTAP9-4
MAPK10
MAPK8
MAPK9
MDFI
MEOX2
NOTCH2NL
RGS20
SIAH1
SPRY2
TCF12
TCF4
TEX11
TRIM27
TRIP6
34 interactors:
APP
ARRB1
ARRB2
ATF2
BCL2L11
CDK5
CDKN1B
CDKN2A
CDKN2C
CEP290
CREBBP
DUSP10
DUSP16
ELK1
GTF3C1
HAX1
HDAC9
HNRNPK
JUN
KIF26A
LDHA
MAP2K4
MAPK8IP2
MAPK8IP3
MAPKBP1
MCL1
PKMYT1
PLIN2
RELA
SH3BP5
STMN2
TNIP1
TP53
UNC119
Entrez ID
23005
5602
HPRD ID
17465
04207
Ensembl ID
ENSG00000137802
ENSG00000109339
Uniprot IDs
O60336
A8MWW6
P53779
Q499Y8
PDB IDs
1JNK
1PMN
1PMQ
1PMU
1PMV
2B1P
2EXC
2O0U
2O2U
2OK1
2P33
2R9S
2WAJ
2ZDT
2ZDU
3CGF
3CGO
3DA6
3FI2
3FI3
3FV8
3G90
3G9L
3G9N
3KVX
3OXI
3OY1
3PTG
3RTP
3TTI
3TTJ
3V6R
3V6S
4H36
4H39
4H3B
Enriched GO Terms of Interacting Partners
?
JUN Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
Regulation Of Gene Expression
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Circadian Rhythm
Signal Transduction By Phosphorylation
Toll-like Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Apoptotic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Cell Death
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Metabolic Process
Activation Of Innate Immune Response
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Localization
Regulation Of Intracellular Transport
Positive Regulation Of Innate Immune Response
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Positive Regulation Of Apoptotic Signaling Pathway
Developmental Process
Regulation Of Nucleocytoplasmic Transport
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Phosphorylation
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Kinase Activity
Positive Regulation Of Neuron Death
Regulation Of Kinase Activity
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Catalytic Activity
Regulation Of Intracellular Signal Transduction
Stress-activated MAPK Cascade
Regulation Of Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Apoptotic Mitochondrial Changes
Cell Communication
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Response To Abiotic Stimulus
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Innate Immune Response
Cellular Response To Stimulus
Regulation Of Signaling
Apoptotic Process
Regulation Of Metabolic Process
Response To Stimulus
Negative Regulation Of Catalytic Activity
Cellular Response To Stress
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Cell Death
Death
Positive Regulation Of Transcription, DNA-templated
Toll-like Receptor Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Developmental Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
map2k2
map2k7
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?