HRSP12 and TRIB3

Number of citations of the paper that reports this interaction (PMID 18276110)
7

Data Source:
BioGRID (two hybrid)

		HRSP12	TRIB3
Gene Name		heat-responsive protein 12	tribbles pseudokinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Endonuclease Activity Deaminase Activity Poly(A) RNA Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Regulation Of Translational Termination Nucleic Acid Phosphodiester Bond Hydrolysis	Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Glucose Transport Positive Regulation Of Protein Binding Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways			Signaling by the B Cell Receptor (BCR) Metabolism of lipids and lipoproteins Signaling by FGFR in disease Activation of PKB Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System PPARA activates gene expression Costimulation by the CD28 family Activation of PKB PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PI3K Cascade
Drugs		Benzoic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)	Information processing speed ( 21130836)
Protein-Protein Interactions		9 interactors: COX2 DEAF1 HIVEP1 HPD MDM2 SERPINA5 SPEN TMEM176A TRIB3	21 interactors: AKT1 AKT2 APP ATF4 BMPR2 COPS6 DDIT3 EEF1G GDF9 GIT1 HLA-B HRSP12 KAT5 PRMT5 PSMA3 RBM4 RBM48 RELA RPGRIP1 RPSA SETDB1
Entrez ID		10247	57761
HPRD ID		03924	09836
Ensembl ID		ENSG00000132541	ENSG00000101255
Uniprot IDs		P52758	J3KR25 Q96RU7
PDB IDs		1ONI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Response To Light Stimulus Cellular Response To UV Maintenance Of Blood-brain Barrier Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Fatty Acid Metabolic Process Response To Radiation Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Vitamin Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Oxygen Levels Defense Response Regulation Of Fat Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Production Response To UV Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Learning Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Gamete Generation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Differentiation Tyrosine Catabolic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Dendritic Cell Differentiation Response To Carbohydrate Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Gene Expression Cellular Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Translation Viral Process Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Gene Expression Response To Nutrient Levels Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Posttranscriptional Regulation Of Gene Expression Response To Extracellular Stimulus Signal Transduction Peripheral Nervous System Myelin Maintenance Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Regulation Of Cytokine Production Regulation Of Lipid Transport Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Signaling RNA Metabolic Process Regulation Of Fatty Acid Beta-oxidation Apoptotic Process
Tagcloud ?			6weeks amounts atf attenuation caspase3 chop db diabetic ebp endoplasmic glp homolog homologous immunoblot inhibiting islets nuclei orally promoted promotes reticulum staining tribbles triggers tunel untreated vildagliptin vs x10
Tagcloud (Difference) ?			6weeks amounts atf attenuation caspase3 chop db diabetic ebp endoplasmic glp homolog homologous immunoblot inhibiting islets nuclei orally promoted promotes reticulum staining tribbles triggers tunel untreated vildagliptin vs x10
Tagcloud (Intersection) ?