HRSP12 and SPEN

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HRSP12	SPEN
Gene Name		heat-responsive protein 12	spen family transcriptional repressor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Extracellular Vesicular Exosome	Nucleoplasm Transcriptional Repressor Complex Extracellular Vesicular Exosome
	Molecular Function	Endonuclease Activity Deaminase Activity Poly(A) RNA Binding	Nucleotide Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Translational Termination Nucleic Acid Phosphodiester Bond Hydrolysis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis
Pathways
Drugs		Benzoic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: COX2 DEAF1 HIVEP1 HPD MDM2 SERPINA5 SPEN TMEM176A TRIB3	20 interactors: ATXN1 CTBP1 DLX5 HDAC1 HDAC2 HRSP12 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RUNX1 RUNX1T1 SERTAD1 SOX9 UBE2L6
Entrez ID		10247	23013
HPRD ID		03924	10230
Ensembl ID		ENSG00000132541	ENSG00000065526
Uniprot IDs		P52758	Q96T58
PDB IDs		1ONI	1OW1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Response To Light Stimulus Cellular Response To UV Maintenance Of Blood-brain Barrier Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Fatty Acid Metabolic Process Response To Radiation Cellular Response To Light Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Vitamin Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Oxygen Levels Defense Response Regulation Of Fat Cell Differentiation Positive Regulation Of Fibroblast Growth Factor Production Response To UV Regulation Of Lipid Biosynthetic Process Phosphatidylinositol-mediated Signaling Learning Cellular Response To Radiation Positive Regulation Of Cellular Metabolic Process Gamete Generation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Differentiation Tyrosine Catabolic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Dendritic Cell Differentiation Response To Carbohydrate Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Organization ATP-dependent Chromatin Remodeling Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryo Development Chromatin Remodeling Positive Regulation Of Gene Expression Hair Follicle Development Hair Cycle Process Limb Development Positive Regulation Of Cellular Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Chromatin Modification Response To Growth Factor Hair Cycle Tissue Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Organ Morphogenesis
Tagcloud ?			15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311
Tagcloud (Difference) ?			15q25 5p15 6p21 adca bag6 ebln2 entirely exome germline gon4l gwas kiaa2018 nelfe nop58 players polygenic predispose predisposition rbmx reproducible sib sibling sibs smokers taf1b tceb3c truncating wisp3 znf311
Tagcloud (Intersection) ?