RIDA and HPD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RIDA	HPD
Description		reactive intermediate imine deaminase A	4-hydroxyphenylpyruvate dioxygenase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding Hydrolase Activity RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase 2-iminobutanoate Deaminase Activity 2-iminopropanoate Deaminase Activity	4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Protein Homodimerization Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	MRNA Catabolic Process Lipid Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Translation L-threonine Catabolic Process To Glycine MRNA Destabilization Regulation Of Primary Metabolic Process	L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Aromatic Amino Acid Metabolic Process
Pathways		Threonine catabolism	Tyrosine catabolism
Drugs			Nitisinone DAS869
Diseases			Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS			HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407)
Interacting Genes		10 interacting genes: BANP DEAF1 HIVEP1 HPD MDM2 MT-CO2 SERPINA5 SPEN TMEM176A TRIB3	5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33
Entrez ID		10247	3242
HPRD ID		03924	02041
Ensembl ID		ENSG00000132541	ENSG00000158104
Uniprot IDs		P52758	P32754
PDB IDs		1ONI	3ISQ 5EC3 8IM2 8IM3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body 4-hydroxyphenylpyruvate Dioxygenase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Seminal Clot Liquefaction Response To Vitamin B1 Response To Water-immersion Restraint Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Platelet Dense Tubular Network Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Proteasomal Protein Catabolic Process Acrosin Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To UV-C Ubiquitin-protein Transferase Regulator Activity	Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Proliferation Cyclin Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Cyclin D2-CDK6 Complex Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic DNA Integrity Checkpoint Signaling Mitotic DNA Damage Checkpoint Signaling 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Cyclin D3-CDK6 Complex Regulation Of Fibroblast Proliferation Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle FBXO Family Protein Binding PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration DNA Damage Checkpoint Signaling L-threonine Catabolic Process Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Linear Polyubiquitin Binding Threonine Metabolic Process Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cellular Response To Cell-matrix Adhesion Positive Regulation Of Metabolic Process Gliogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Oncogene-induced Cell Senescence Stress-induced Premature Senescence Negative Regulation Of Mitotic Cell Cycle IkappaB Kinase Complex Manchette Assembly Negative Regulation Of Cell Cycle Phase Transition Nucleus Deaminase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?