TRIM13 and GMCL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRIM13	GMCL1
Description		tripartite motif containing 13	germ cell-less 1, spermatogenesis associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Endoplasmic Reticulum	Nucleus Nuclear Matrix
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Immune System Process Positive Regulation Of Macroautophagy Protein Ubiquitination Negative Regulation Of Viral Transcription ERAD Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming	Germ Cell Development Spermatogenesis Cell Differentiation
Pathways		ER Quality Control Compartment (ERQC)
Drugs		Etorphine Diprenorphine Dihydromorphine
Diseases
GWAS		Diastolic blood pressure ( 30224653) Height ( 23563607) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)
Interacting Genes		16 interacting genes: AKT1 ARHGDIA CCNA1 CDC34 GMCL1 MDM2 ROBO2 UBE2C UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2N	98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250
Entrez ID		10206	64395
HPRD ID		10414	13587
Ensembl ID		ENSG00000204977	ENSG00000087338
Uniprot IDs		O60858	Q53SE7 Q96IK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Protein K11-linked Ubiquitination Protein Modification Process Transferase Activity Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ATP Binding Proteasomal Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex Nucleus ISG15 Transferase Activity Cytosol ISG15-protein Conjugation Cell Cycle Phase Transition Free Ubiquitin Chain Polymerization Protein Monoubiquitination Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Ubiquitin-protein Transferase Activator Activity Protein Autoubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Mitotic Cell Cycle Phase Transition Ubiquitin Binding Nucleoplasm Positive Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Phase Transition Response To Ether Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Cell Cycle Cellular Response To Hormone Stimulus Regulation Of Protein Modification Process Negative Regulation Of Protein Maturation	Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process
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