TRIM13 and ARHGDIA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TRIM13	ARHGDIA
Gene Name		tripartite motif containing 13	Rho GDP dissociation inhibitor (GDI) alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane Perinuclear Endoplasmic Reticulum	Immunological Synapse Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Anatomical Structure Morphogenesis Response To Gamma Radiation Positive Regulation Of Cell Death Positive Regulation Of Macroautophagy ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Negative Regulation Of Viral Release From Host Cell	Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Migration Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways			Rho GTPase cycle Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis Axonal growth stimulation Signaling by Rho GTPases p75 NTR receptor-mediated signalling
Drugs		Etorphine Diprenorphine Dihydromorphine
Diseases
GWAS		Height ( 23563607)
Protein-Protein Interactions		4 interactors: ARHGDIA GMCL1 ROBO2 UBE2D2	36 interactors: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B FEN1 HAAO HERPUD1 IKBKG JUP MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		10206	396
HPRD ID		10414	03565
Ensembl ID		ENSG00000204977	ENSG00000141522
Uniprot IDs		O60858	J3QQX2 J3QW41 P52565
PDB IDs			1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Axonogenesis Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Positive Regulation Of Neuron Projection Development Regulation Of Negative Chemotaxis Negative Regulation Of Locomotion Luteolysis Axon Midline Choice Point Recognition Positive Regulation Of Cell Projection Organization Axon Choice Point Recognition Positive Regulation Of Neuron Differentiation Olfactory Bulb Interneuron Development Regulation Of Neuron Projection Development Positive Regulation Of Neurogenesis Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Olfactory Bulb Interneuron Differentiation Positive Regulation Of Cell Development Negative Regulation Of Synapse Assembly Regulation Of Neuron Differentiation Retinal Ganglion Cell Axon Guidance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chemotaxis Apoptotic Process Involved In Development Regulation Of Locomotion Regulation Of Neurogenesis Forebrain Neuron Development Neuron Recognition Protein K48-linked Ubiquitination Multicellular Organismal Reproductive Process Olfactory Bulb Development Multicellular Organism Reproduction Semaphorin-plexin Signaling Pathway Regulation Of Cell Development Positive Regulation Of Cell Differentiation Olfactory Lobe Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Rho Protein Signal Transduction Regulation Of Synapse Assembly Forebrain Neuron Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Axonogenesis Reproduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Forebrain Generation Of Neurons	Response To Stress Response To Stimulus Cellular Response To Stimulus Homeostatic Process Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction Positive Regulation Of Cell Death Signaling Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Component Biogenesis Cell Communication Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Catalytic Activity Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Programmed Cell Death Small GTPase Mediated Signal Transduction Blood Coagulation Regulation Of Telomere Maintenance Hemostasis Response To Abiotic Stimulus Regulation Of Signaling Telomere Maintenance Regulation Of Catalytic Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Lamellipodium Assembly Response To Wounding Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Organic Substance
Tagcloud ?		anchored autophagy clonogenic dysregulation e3 endoplasmic essential hence ikk interacts kappab ligase modification modulates nemo neurodegenerative nf opposite regulator represses repression resident reticulum ring steps stimuli translational turnover ubiquitination	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Difference) ?		anchored autophagy clonogenic dysregulation e3 endoplasmic essential ikk interacts kappab ligase modification modulates nemo neurodegenerative nf opposite regulator represses resident reticulum ring steps stimuli translational turnover ubiquitination	3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators separate serve snai2 untranslated utr
Tagcloud (Intersection) ?		hence repression