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TTC1 and GNA15
Number of citations of the paper that reports this interaction (PMID
12748287
)
14
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
TTC1
GNA15
Gene Name
tetratricopeptide repeat domain 1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Peroxisomal Membrane
Heterotrimeric G-protein Complex
Plasma Membrane
Molecular Function
Protein Binding
Unfolded Protein Binding
G-protein Coupled Receptor Binding
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
Biological Process
Protein Folding
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Blood Coagulation
Platelet Activation
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Signaling by GPCR
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
Regulation of insulin secretion
Signal amplification
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
Platelet activation, signaling and aggregation
Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Heart failure (
20445134
)
Protein-Protein Interactions
17 interactors:
ACY1
CRY2
GNA15
GNAI2
GNAQ
GNAS
HRAS
HSPA1A
HSPA4
HSPA8
NDE1
RNF41
SH3BP4
SOX5
SPP1
SREBF2
TGFBR1
19 interactors:
ADRB2
ADRBK1
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
Entrez ID
7265
2769
HPRD ID
11881
00760
Ensembl ID
ENSG00000113312
ENSG00000060558
Uniprot IDs
Q99614
P30679
PDB IDs
Enriched GO Terms of Interacting Partners
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Cellular Response To Stimulus
Response To Stimulus
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Dopamine Receptor Signaling Pathway
Response To Organic Substance
Wound Healing
Positive Regulation Of Metabolic Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Response To Stress
Regulation Of Cell Differentiation
Response To Wounding
Blood Coagulation
Platelet Activation
Hemostasis
Activation Of MAPKK Activity
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Growth
Regulation Of Phosphorus Metabolic Process
Regulation Of Body Fluid Levels
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Regulation Of Growth
Generation Of Neurons
Neurogenesis
Negative Regulation Of Cell Proliferation
Cell Activation
Regulation Of Cell Growth
Protein Refolding
Regulation Of Catalytic Activity
Response To Unfolded Protein
Post-embryonic Development
Locomotion
Negative Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Negative Regulation Of Cell Growth
Regulation Of Cellular Response To Heat
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of GTPase Activity
Regulation Of Signal Transduction
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Proliferation
Positive Regulation Of Catalytic Activity
Skeletal System Development
Regulation Of Gene Expression
Nervous System Development
Activation Of Phospholipase C Activity
Regulation Of Signaling
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Phospholipase C Activity
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Defense Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Signaling
Cell Communication
Sensory Perception Of Pain
Cellular Metal Ion Homeostasis
Inflammatory Response
Response To External Stimulus
Opioid Receptor Signaling Pathway
Cellular Cation Homeostasis
Cellular Response To Stimulus
Cellular Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Phosphorus Metabolic Process
Cellular Chemical Homeostasis
Blood Circulation
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Muscle Contraction
Response To Stress
Chemical Homeostasis
Ion Homeostasis
Synaptic Transmission
Regulation Of Cyclase Activity
Immune Response
Regulation Of Phosphorylation
Cytosolic Calcium Ion Homeostasis
Regulation Of MAPK Cascade
Regulation Of Catalytic Activity
Homeostatic Process
Regulation Of Signaling
Interleukin-8-mediated Signaling Pathway
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Cellular Homeostasis
Negative Regulation Of Muscle Contraction
Negative Regulation Of Adenylate Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Response To Stimulus
Regulation Of CAMP Metabolic Process
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Catalytic Activity
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Tagcloud (Intersection)
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