TTC1 and ACY1

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		TTC1	ACY1
Name		tetratricopeptide repeat domain 1	aminoacylase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisomal Membrane Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Unfolded Protein Binding	Aminoacylase Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Inflammatory Response Positive Regulation Of Inflammatory Response Chemokine-mediated Signaling Pathway Positive Regulation Of Neuroinflammatory Response	Amino Acid Metabolic Process
Pathways		None	Aflatoxin activation and detoxification Defective ACY1 causes encephalopathy Paracetamol ADME
Drugs		None	Aspartic acid Acetylcysteine Copper
GWAS		Diastolic blood pressure ( 27841878 ) Hemoglobin levels ( 32327693 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )	Serum metabolite concentrations in chronic kidney disease ( 33838163 )
Interacting Genes		19 interacting genes: ACY1 CRY2 CYB5R1 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 PSTPIP1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1	11 interacting genes: APP BCAS2 NPM1 NTAQ1 POT1 PRR35 TENT5B TERF1 TLX3 TTC1 WWOX
Entrez ID		7265	95
HPRD ID		11881	00092
Ensembl ID		ENSG00000113312	ENSG00000243989
Uniprot IDs		Q99614	Q03154 V9HWA0
PDB IDs		Not available	1Q7L
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Signaling Pathway Nucleotide Binding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding Acetylcholine Receptor Signaling Pathway Extracellular Exosome GTPase Activity Postsynaptic Signal Transduction ATP-dependent Protein Disaggregase Activity GTP Binding Response To Hormone Regulation Of Cell Communication Regulation Of Signaling G Protein Activity Signal Transduction Perinuclear Region Of Cytoplasm Negative Regulation Of Growth Regulation Of Signal Transduction Response To Unfolded Protein Response To Lipid Cellular Response To Laminar Fluid Shear Stress Cellular Response To Acidic PH Response To Laminar Fluid Shear Stress Chaperone-mediated Protein Complex Assembly Response To Acidic PH Cellular Response To PH Response To Prostaglandin E Regulation Of Growth Protein Refolding Entrainment Of Circadian Clock Regulation Of Multicellular Organismal Process Regulation Of Lipid Transport Cellular Response To Fluid Shear Stress Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Lipid Transport Negative Regulation Of Cell Growth FAD Binding Response To PH Regulation Of Cell Growth Cytosol Photoreactive Repair Regulation Of Transport Response To Fluid Shear Stress Negative Regulation Of Cell Population Proliferation Chaperone-mediated Autophagy Translocation Complex Disassembly	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein-N-terminal Glutamine Amidohydrolase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process