RRM2B and RRM1

Number of citations of the paper that reports this interaction (PMID 11517226)
38

Data Source:
HPRD (in vivo)

		RRM2B	RRM1
Gene Name		ribonucleotide reductase M2 B (TP53 inducible)	ribonucleotide reductase M1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Small Molecule Metabolic Process Protein Heterotetramerization Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Retina Development In Camera-type Eye
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MDM2 ORC4 RRM1 RRM2 TP53	8 interactors: BMI1 KAT5 LRIF1 PPP1CC RNF2 RRM2 RRM2B YWHAG
Entrez ID		50484	6240
HPRD ID		05276	01588
Ensembl ID		ENSG00000048392	ENSG00000167325
Uniprot IDs		B4E2N4 Q7LG56	E9PD78 P23921
PDB IDs		2VUX 3HF1 4DJN	2WGH 3HNC 3HND 3HNE 3HNF
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Protein Tetramerization Deoxyribonucleotide Biosynthetic Process Mitotic Cell Cycle Process Protein Heterotetramerization Nucleobase-containing Small Molecule Interconversion DNA Replication Protein Complex Assembly Cell Cycle Process DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Deoxyribonucleotide Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Protein Oligomerization Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Response To Radiation Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Cellular Component Assembly Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Protein Heterooligomerization Cellular Response To Radiation Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle	Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Histone Ubiquitination Mitotic Cell Cycle Deoxyribonucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Histone Modification DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Acetylation Cell Cycle Internal Peptidyl-lysine Acetylation Histone H2A-K119 Monoubiquitination Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Chromatin Modification Protein Acetylation Positive Regulation Of Immature T Cell Proliferation In Thymus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Immature T Cell Proliferation Cellular Aromatic Compound Metabolic Process Chromatin Organization Biosynthetic Process Regulation Of Gene Expression Organelle Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Histone H2A Monoubiquitination Chromosome Organization Regulation Of Cellular Process Mitochondrial DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Nucleotide Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction Resulting In Transcription
Tagcloud ?		7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred inpp4a intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize segregating singly solute transposable	11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph
Tagcloud (Difference) ?		7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred inpp4a intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize segregating singly solute transposable	11pter 14l a36fc acp2 an2 bisect calc d11s1 d11s12 d11s14 d11s16 d11s17 d11s18 d11s20 d11s21 d11s25 d11s26 d11s30 d11s31 d11s32 d11s33 d11s9 fshb hbvs1 mer2 mic1 mic4 mutagenizing tcl2 trph
Tagcloud (Intersection) ?