RRM2B

Gene Name		ribonucleotide reductase M2 B (TP53 inducible)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Metal Ion Binding
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: MDM2 ORC4 RRM1 RRM2 TP53
Entrez ID		50484
HPRD ID		05276
Ensembl ID		ENSG00000048392
Uniprot IDs		B4E2N4 Q7LG56
PDB IDs		2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Protein Tetramerization Deoxyribonucleotide Biosynthetic Process Mitotic Cell Cycle Process Protein Heterotetramerization Nucleobase-containing Small Molecule Interconversion DNA Replication Protein Complex Assembly Cell Cycle Process DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Deoxyribonucleotide Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Protein Oligomerization Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Response To Radiation Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Cellular Response To Decreased Oxygen Levels Cellular Component Assembly Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Regulation Of Cell Cycle G1/S Phase Transition Protein Heterooligomerization Cellular Response To Radiation Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		7a abcc2 carboplatin chemotoxicity dspr fecundity founder gemcitabine gpx4 inbred inpp4a intercross interindividual mitomycin msh2 multiparent nalcn nonsynonymous ortholog orthologs posteriori priori qtl revolutionize segregating singly solute transposable