RRM2B and ORC4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RRM2B	ORC4
Description		ribonucleotide reductase regulatory TP53 inducible subunit M2B	origin recognition complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	DNA Synthesis Involved In DNA Repair Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair DNA Damage Response Response To Oxidative Stress Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Amine Positive Regulation Of G0 To G1 Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization
Pathways		Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs		Cladribine
Diseases		Mitochondrial DNA depletion syndrome (MDS)	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Blood protein levels ( 30072576) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)	Estimated glomerular filtration rate ( 30604766 31015462 31152163) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: CDKN1A CSNK2A1 MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4
Entrez ID		50484	5000
HPRD ID		05276	09118
Ensembl ID		ENSG00000048392	ENSG00000115947
Uniprot IDs		Q7LG56	A8K7H4 O43929 Q96B14
PDB IDs		2VUX 3HF1 4DJN	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Cell Cycle Process Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Actinomycin D Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Response To Actinomycin D DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Gamma Radiation Regulation Of Mitotic Cell Cycle Cellular Response To UV-C Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Metabolic Process Stress-induced Premature Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Antibiotic Protein-containing Complex Assembly Protein Tetramerization Signal Transduction By P53 Class Mediator DNA Damage Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Mitophagy Cellular Response To Light Stimulus Protein-containing Complex Organization DNA Damage Response Response To UV-C Replicative Senescence Positive Regulation Of Cell Cycle Phase Transition 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Cytosol Regulation Of Signal Transduction By P53 Class Mediator Cellular Component Assembly Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process	DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
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