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ARID4A and CCNA2
Number of citations of the paper that reports this interaction (PubMedID
21148318
)
61
Data Source:
BioGRID
(enzymatic study)
ARID4A
CCNA2
Description
AT-rich interaction domain 4A
cyclin A2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Transcription Repressor Complex
Sin3-type Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Cyclin A2-CDK1 Complex
Cyclin A2-CDK2 Complex
Molecular Function
Transcription Cis-regulatory Region Binding
DNA Binding
Double-stranded DNA Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Spermatogenesis
Cell Differentiation
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Genomic Imprinting
Establishment Of Sertoli Cell Barrier
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of DNA Replication
DNA-templated Transcription
Ras Protein Signal Transduction
Animal Organ Regeneration
Response To Estradiol
Response To Glucagon
Cellular Response To Platelet-derived Growth Factor Stimulus
Post-translational Protein Modification
Cellular Response To Leptin Stimulus
Mitotic Cell Cycle Phase Transition
Cell Cycle G1/S Phase Transition
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Fibroblast Proliferation
Cell Division
Cellular Response To Cocaine
Cellular Response To Luteinizing Hormone Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Nitric Oxide
Cochlea Development
Cellular Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of DNA Biosynthetic Process
Pathways
HDACs deacetylate histones
Potential therapeutics for SARS
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine
6-O-Cyclohexylmethyl Guanine
[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine
4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide
N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE
5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID
N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM
4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine
6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol
3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE
4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE
Variolin B
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Alcohol consumption (drinks per week) (
30679032
)
Alcohol consumption in current drinkers (
28937693
)
Brain morphology (MOSTest) (
32665545
)
Coronary artery disease (
29212778
33020668
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Problematic alcohol use (
32451486
)
Venous thromboembolism (
31420334
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
15 interacting genes:
BRMS1
CCNA2
CCNB1
CCND1
CCNE1
CDK1
CDK2
CDK4
EID1
H3C14
H4C16
HDAC1
HDAC2
HDAC3
SIN3A
46 interacting genes:
ARID4A
BRCA1
BRCA2
BTG1
BUB1B
CALM1
CDC20
CDC25C
CDC6
CDK1
CDK2
CDK3
CDKN1A
CDKN1B
CDT1
DTNBP1
E2F1
E2F3
FANCC
FEN1
H1-1
H1-5
HERC5
HIRA
ITGB3BP
KAT2B
MAD2L1
MAGEA11
MYBL2
NFYA
PGR
PRC1
PSMD4
PTMA
RAD23A
RB1
RBL1
RBL2
SKP1
SKP2
SP1
TAF1
TP53
TRAF3IP1
UBTF
USP37
Entrez ID
5926
890
HPRD ID
01575
00453
Ensembl ID
ENSG00000032219
ENSG00000145386
Uniprot IDs
P29374
Q05CG0
P20248
PDB IDs
2LCC
2MAM
2YRV
6BPH
6L87
7SMC
7V8N
1E9H
1FIN
1FVV
1GY3
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1JST
1JSU
1OGU
1OI9
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P5E
1PKD
1QMZ
1URC
1VYW
2BKZ
2BPM
2C4G
2C5N
2C5O
2C5V
2C5X
2C6T
2CCH
2CCI
2CJM
2I40
2IW6
2IW8
2IW9
2UUE
2UZB
2UZD
2UZE
2UZL
2V22
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
3EID
3EJ1
3EOC
3F5X
4BCK
4BCM
4BCN
4BCP
4CFM
4CFN
4CFU
4CFV
4CFW
4CFX
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4FX3
5CYI
5IF1
5LMK
5NEV
6ATH
6GVA
6P3W
6Q6G
6Q6H
6RIJ
6SG4
7ACK
7B5L
7B5R
7B7S
7LUO
7MKX
7QHL
8B54
8BYA
8BZO
Enriched GO Terms of Interacting Partners
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Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Cycle Phase Transition
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Positive Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Nucleoplasm
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Protein Lysine Delactylase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle
Regulation Of RNA Metabolic Process
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Regulation Of Mitotic Cell Cycle
Sin3-type Complex
Negative Regulation Of Stem Cell Population Maintenance
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
NF-kappaB Binding
Cyclin Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Chromatin Remodeling
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Histone Deacetylase Complex
Cell Division
Positive Regulation Of Cell Cycle Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Activity, Hydrolytic Mechanism
Histone Deacetylase Binding
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Gene Expression
Chromatin Organization
Cell Cycle G2/M Phase Transition
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Nucleus
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Regulation Of Cell Cycle G1/S Phase Transition
Cell Division
Regulation Of DNA Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Chromosome Organization
Regulation Of DNA Replication
Positive Regulation Of Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Chromatin Remodeling
Chromosome Organization
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Cell Cycle G2/M Phase Transition
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Sister Chromatid Segregation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Population Proliferation
Cyclin Binding
Positive Regulation Of Cell Cycle Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Chromosome Segregation
Mitotic Checkpoint Complex
Regulation Of Lipid Kinase Activity
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