ARID4A

Description		AT-rich interaction domain 4A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Transcription Repressor Complex Sin3-type Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Cell Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Genomic Imprinting Establishment Of Sertoli Cell Barrier Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption in current drinkers ( 28937693) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Problematic alcohol use ( 32451486) Venous thromboembolism ( 31420334) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		15 interacting genes: BRMS1 CCNA2 CCNB1 CCND1 CCNE1 CDK1 CDK2 CDK4 EID1 H3C14 H4C16 HDAC1 HDAC2 HDAC3 SIN3A
Entrez ID		5926
HPRD ID		01575
Ensembl ID		ENSG00000032219
Uniprot IDs		P29374 Q05CG0
PDB IDs		2LCC 2MAM 2YRV 6BPH 6L87 7SMC 7V8N
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Protein Lysine Delactylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Mitotic Cell Cycle Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process NF-kappaB Binding Cyclin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Histone Deacetylase Complex Cell Division Positive Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Chromatin Organization Cell Cycle G2/M Phase Transition
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