CCDC53 and NDC80

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		CCDC53	NDC80
Gene Name		coiled-coil domain containing 53	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Intracellular Membrane-bounded Organelle WASH Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Biological_process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ABI2 BLOC1S6 CCHCR1 CEP55 CKAP4 DTNBP1 GDF9 GOLGA2 HAUS1 HSBP1 IFT20 KDM1A KRT6A LAMC1 LUC7L2 MCRS1 MOB1B NDC80 NUP62 OPTN PBXIP1 PCM1 PTN SDCBP SNAP25 SYCE1 TXLNA TXLNB	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		51019	10403
HPRD ID		13031	06277
Ensembl ID		ENSG00000120860	ENSG00000080986
Uniprot IDs		F5GZ97 Q9Y3C0	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Differentiation Establishment Of Localization In Cell Organelle Localization Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Developmental Process Synaptic Vesicle Docking Cell Cycle Mitotic Cell Cycle Process Cell Development Nervous System Development Cell Cycle Process Protein Localization Post-Golgi Vesicle-mediated Transport Microtubule-based Process Intracellular Transport Generation Of Neurons Cell Projection Organization Anterograde Synaptic Vesicle Transport Synaptic Vesicle Transport Membrane Organization Neurogenesis Melanosome Organization Pigment Granule Organization Microtubule-based Movement Anterograde Axon Cargo Transport Establishment Of Organelle Localization Neuron Development Cellular Process Multicellular Organismal Development Cellular Component Assembly Intraciliary Transport Establishment Of Protein Localization Anatomical Structure Development Movement Of Cell Or Subcellular Component Protein Localization To Golgi Apparatus Cytoskeleton Organization Neuron Differentiation Cell Division Regulation Of Primitive Erythrocyte Differentiation Opsin Transport Establishment Of Vesicle Localization Axon Cargo Transport Vesicle Organization Vesicle Localization Neuron Projection Development Positive Regulation Of Cell Proliferation See more	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle See more
Tagcloud ?			assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?			assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?