GLUL and TAT

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		GLUL	TAT
Description		glutamate-ammonia ligase	tyrosine aminotransferase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cell Body Extracellular Exosome Glial Cell Projection	Cellular_component Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Glutamine Synthetase Activity Protein Binding ATP Binding Transferase Activity Ligase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding	Catalytic Activity L-tyrosine-2-oxoglutarate Transaminase Activity Protein Binding Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Angiogenesis L-glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ribosome Biogenesis Positive Regulation Of Erythrocyte Differentiation Intracellular Ammonium Homeostasis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus	2-oxoglutarate Metabolic Process Amino Acid Metabolic Process Glutamate Metabolic Process L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Response To Oxidative Stress Aromatic Amino Acid Metabolic Process Aromatic Amino Acid Family Catabolic Process Response To Mercury Ion Response To Glucocorticoid Response To Dexamethasone
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism	Tyrosine catabolism
Drugs		L-Glutamine Glutamic acid	Pyridoxal phosphate Phenylalanine Tyrosine Glutamic acid
Diseases		Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency	Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823) Peak height velocity ( 34047840)	Chronotype ( 30696823) Metabolite levels ( 22286219 22916037) Morning person ( 30696823) Urate levels ( 31578528)
Interacting Genes		27 interacting genes: BTG3 CASP8AP2 CRBN CYP39A1 DSCAM DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A LCOR MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 RSPH1 SKIL TAT UBE2I USP15	3 interacting genes: GLUL GRN UBE3A
Entrez ID		2752	6898
HPRD ID		00701	11776
Ensembl ID		ENSG00000135821	ENSG00000198650
Uniprot IDs		A8YXX4 P15104	A0A140VKB7 P17735
PDB IDs		2OJW 2QC8 7EVT 8DNU	3DYD
Enriched GO Terms of Interacting Partners?		PML Body SUMO Transferase Activity SUMO Ligase Activity Transcription Coregulator Activity Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Purine Ribonucleoside Diphosphate Catabolic Process Transcription Coactivator Binding Nucleoside Diphosphate Catabolic Process Protein Modification Process Apoptotic Signaling Pathway Positive Regulation Of Protein Sumoylation Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoside Diphosphate Metabolic Process Transcription Corepressor Activity Positive Regulation Of Cell Differentiation Apoptotic Process Purine Nucleotide Catabolic Process Negative Regulation Of Biosynthetic Process Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death Cell Death Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Bile Acid Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Nucleotide Catabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Developmental Process Retina Layer Formation Extrinsic Apoptotic Signaling Pathway Organic Acid Metabolic Process Purine Ribonucleotide Metabolic Process Nucleobase-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy	Intracellular Chemical Homeostasis Intracellular PH Reduction Cellular Homeostasis Regulation Of Cellular PH Regulation Of Intracellular PH Intracellular Ammonium Homeostasis Chemical Homeostasis Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of PH Sperm Entry Positive Regulation Of Golgi Lumen Acidification Glutamine Synthetase Activity Glutamine Biosynthetic Process Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Endothelial Cell Migration Homeostatic Process Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Regulation Of Golgi Lumen Acidification Cellular Response To Nutrient Levels Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Trophectodermal Cell Proliferation Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Cellular PH Reduction Ammonium Homeostasis Regulation Of Angiogenesis Negative Regulation Of Respiratory Burst Positive Regulation Of Protein Localization To Lysosome Regulation Of Vasculature Development L-glutamate Catabolic Process Catabolic Process Negative Regulation Of Neutrophil Activation Negative Regulation Of Microglial Cell Activation Regulation Of Respiratory Burst Involved In Inflammatory Response Cerebellar Climbing Fiber To Purkinje Cell Synapse Regulation Of Proteolysis Positive Regulation Of Axon Regeneration Intracellular Monoatomic Cation Homeostasis Regulation Of Protein Folding Intracellular Monoatomic Ion Homeostasis Prostate Gland Growth Regulation Of Protein Localization To Nucleolus Regulation Of Neutrophil Activation Positive Regulation Of Peptidase Activity Positive Regulation Of Defense Response To Bacterium Progesterone Receptor Signaling Pathway Response To Nutrient Levels Monoatomic Ion Homeostasis
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