GLUL and NUDT18

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GLUL	NUDT18
Description		glutamate-ammonia ligase	nudix hydrolase 18
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cell Body Extracellular Exosome Glial Cell Projection	Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Glutamine Synthetase Activity Protein Binding ATP Binding Transferase Activity Ligase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity Metal Ion Binding
	Biological Process	Angiogenesis L-glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ribosome Biogenesis Positive Regulation Of Erythrocyte Differentiation Intracellular Ammonium Homeostasis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus	Nucleotide Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs		L-Glutamine Glutamic acid
Diseases		Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823) Peak height velocity ( 34047840)
Interacting Genes		27 interacting genes: BTG3 CASP8AP2 CRBN CYP39A1 DSCAM DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A LCOR MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 RSPH1 SKIL TAT UBE2I USP15	34 interacting genes: APIP CAVIN2 COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		2752	79873
HPRD ID		00701	07992
Ensembl ID		ENSG00000135821	ENSG00000275074
Uniprot IDs		A8YXX4 P15104	Q6ZVK8
PDB IDs		2OJW 2QC8 7EVT 8DNU	3GG6 4HVY
Enriched GO Terms of Interacting Partners?		PML Body SUMO Transferase Activity SUMO Ligase Activity Transcription Coregulator Activity Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Purine Ribonucleoside Diphosphate Catabolic Process Transcription Coactivator Binding Nucleoside Diphosphate Catabolic Process Protein Modification Process Apoptotic Signaling Pathway Positive Regulation Of Protein Sumoylation Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoside Diphosphate Metabolic Process Transcription Corepressor Activity Positive Regulation Of Cell Differentiation Apoptotic Process Purine Nucleotide Catabolic Process Negative Regulation Of Biosynthetic Process Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death Cell Death Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Bile Acid Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Nucleotide Catabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Developmental Process Retina Layer Formation Extrinsic Apoptotic Signaling Pathway Organic Acid Metabolic Process Purine Ribonucleotide Metabolic Process Nucleobase-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy	Identical Protein Binding DUMP Biosynthetic Process DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Negative Regulation Of Defense Response To Virus By Host Protein Complex Oligomerization Protein Homooligomerization Pyrimidine Deoxyribonucleotide Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Deoxyribonucleotide Metabolic Process Cytosol Nucleoside Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Protein Binding Amino Acid Biosynthetic Process L-amino Acid Metabolic Process Small Molecule Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Methionine Metabolic Process Negative Regulation Of Defense Response To Virus Alpha-amino Acid Metabolic Process Protein-containing Complex Assembly IMP Metabolic Process Nucleotide Biosynthetic Process Purine Nucleobase Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Nucleotide Metabolic Process Purine Nucleoside Metabolic Process Pyrimidine Nucleotide Biosynthetic Process Deoxyhypusine Synthase Activity Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process DUTP Catabolic Process DUTP Diphosphatase Activity Amino Acid Metabolic Process Intracellular Ammonium Homeostasis Tumor Necrosis Factor Receptor Binding Regulation Of SiRNA Processing Protein-containing Complex Organization TORC2 Complex Disassembly Protein Autosumoylation Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity GMP Metabolic Process Phosphoribosylaminoimidazole Carboxylase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Tubulin N-terminal-methionine Acetyltransferase Activity
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