GLUL

Gene Name		glutamate-ammonia ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Perikaryon Protein Complex Axon Terminus Extracellular Vesicular Exosome Glial Cell Projection
	Molecular Function	Magnesium Ion Binding Glutamate Decarboxylase Activity Glutamate-ammonia Ligase Activity ATP Binding Glutamate Binding Manganese Ion Binding Identical Protein Binding Dynein Light Chain Binding
	Biological Process	Neurotransmitter Uptake Glutamate Catabolic Process Glutamine Biosynthetic Process Synaptic Transmission Cell Proliferation Cellular Amino Acid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Insulin Secretion Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein Homooligomerization Positive Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Neurotransmitter uptake and Metabolism In Glial Cells Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamine L-Glutamic Acid
Diseases
GWAS
Protein-protein Interactions		18 interactors: CASP8AP2 CYP39A1 DYNLL1 HIPK1 HIPK3 HTR2A ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL UBE2I
Entrez ID		2752
HPRD ID		00701
Ensembl ID		ENSG00000135821
Uniprot IDs		A8YXX4 P15104
PDB IDs		2OJW 2QC8
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Transcription, DNA-templated RNA Biosynthetic Process Cell Death Death Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Sumoylation Apoptotic Process Regulation Of Transcription, DNA-templated Gene Expression MRNA Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Protein Sumoylation Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Mechanical Stimulus Regulation Of Cell Death Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation DGDP Catabolic Process DADP Catabolic Process Negative Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		bell bgh bio blots bromo cnp deoxyuridine dlgap2 dor fibrillary gfap gh glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg