RINT1 and TSEN54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RINT1	TSEN54
Description		RAD50 interactor 1	tRNA splicing endonuclease subunit 54
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Dsl1/NZR Complex	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Mitotic G2 DNA Damage Checkpoint Signaling Protein Transport Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing TRNA Processing
Pathways		COPI-dependent Golgi-to-ER retrograde traffic	tRNA processing in the nucleus
Drugs
Diseases			Pontocerebellar hypoplasia
GWAS			Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)
Interacting Genes		101 interacting genes: AIRIM ANKRD11 ARHGAP45 ARNT2 BFSP2 BLOC1S6 BNIP3L C19orf44 C1orf35 CCDC120 CCDC121 CCDC146 CCDC187 CCDC57 CCDC88B CCHCR1 CDR2L CEP57L1 CSPP1 CWF19L2 DCTN2 DCX DPF2 DRC4 EPC1 ESRRG EXOC8 FAM107A FAM110A FAM124B FAM161A FAM161B FAM81B FAM90A1 FANCG FCHSD2 GFI1B GRAP2 HDAC4 HGS INPP5J JMY KIAA1217 KRT1 LMO2 LSP1P3 LYSMD1 MBD3 MCM7 MISP MYOZ3 NAB2 NFIL3 PCM1 PIK3R2 PIMREG PRPF18 PRPF31 PSTPIP1 RAD50 RAMAC RB1 RBL1 RBL2 RBM41 RIBC1 RNF39 RNF6 RSRC2 RTP5 SCNM1 SFR1 SGF29 SH2D4A SMARCB1 SMARCE1 SNW1 SPTBN1 STRN SUOX TACO1 TEX9 TRIM69 TSEN54 TSHZ2 TSHZ3 TXLNA USHBP1 UTP14C VAV3 VPS37C XPNPEP1 ZBTB16 ZC2HC1C ZNF648 ZNF655 ZNF688 ZNF697 ZNF835 ZSCAN5B ZW10	20 interacting genes: BRCA1 CCDC57 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12
Entrez ID		60561	283989
HPRD ID		15250	12291
Ensembl ID		ENSG00000135249	ENSG00000182173
Uniprot IDs		Q6NUQ1	Q7Z6J9
PDB IDs			7UXA 7ZRZ 8HMY 8HMZ 8ISS
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Centrosome SWI/SNF Complex Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition NBAF Complex Nuclear Speck Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Double-strand Break Repair Microtubule Anchoring Centriole Protein Localization To Centrosome Regulation Of Sister Chromatid Segregation Cytoskeleton Organization Nucleoplasm Regulation Of Nucleotide-excision Repair Microtubule Binding	Medial Motor Column Neuron Differentiation
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