BMP2 and MGP

Number of citations of the paper that reports this interaction (PMID 11741887)
41

Data Source:
HPRD (in vitro)

		BMP2	MGP
Gene Name		bone morphogenetic protein 2	matrix Gla protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Proteinaceous Extracellular Matrix Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Retinol Dehydrogenase Activity Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Phosphatase Activator Activity SMAD Binding Protein Heterodimerization Activity BMP Receptor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Structural Constituent Of Bone
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Proliferation Embryo Development Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	Cartilage Condensation Ossification Cell Differentiation Regulation Of Bone Mineralization
Pathways		Molecules associated with elastic fibres Elastic fibre formation Signaling by BMP
Drugs
Diseases
GWAS		Body mass index ( 19079261 23669352) Colorectal cancer ( 23266556) Height ( 20881960 23563607 18391951) Obesity-related traits ( 23251661) Refractive error ( 23396134) Sagittal craniosynostosis ( 23160099)
Protein-Protein Interactions		19 interactors: ACTR2 ACVR1 ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG SOSTDC1 TGFB1 TGFB2	1 interactors: BMP2
Entrez ID		650	4256
HPRD ID		00206	01112
Ensembl ID		ENSG00000125845	ENSG00000111341
Uniprot IDs		C8C060 P12643	P08493
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP
Enriched GO Terms of Interacting Partners?		Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification BMP Signaling Pathway Regulation Of BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Pattern Specification Process Tube Development Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Skeletal System Development Epithelium Development Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Regulation Of Signal Transduction Organ Morphogenesis Multicellular Organismal Development Organ Development Connective Tissue Development Anatomical Structure Development Regulation Of Signaling System Development Positive Regulation Of Bone Mineralization Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Developmental Process Dorsal/ventral Pattern Formation Regulation Of Osteoblast Differentiation Embryonic Morphogenesis Tissue Morphogenesis Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cartilage Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Embryo Development Negative Regulation Of Signaling Regulation Of Cell Differentiation Sensory Organ Development Positive Regulation Of Signal Transduction Mesoderm Development Cell Development Signal Transduction By Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Stem Cell Differentiation	Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Negative Regulation Of Calcium-independent Cell-cell Adhesion Corticotropin Hormone Secreting Cell Differentiation BMP Signaling Pathway Involved In Heart Induction Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process BMP Signaling Pathway Involved In Heart Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Bone Mineralization Involved In Bone Maturation Negative Regulation Of Cardiac Muscle Cell Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Neuroendocrine Cell Differentiation Negative Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Negative Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Odontogenesis Regulation Of Glucocorticoid Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Adenohypophysis Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of P38MAPK Cascade Ossification Involved In Bone Maturation Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Bone Maturation Negative Regulation Of Striated Muscle Cell Differentiation Atrioventricular Valve Morphogenesis Negative Regulation Of Cardiac Muscle Tissue Development Endocardial Cushion Morphogenesis Negative Regulation Of Steroid Biosynthetic Process Atrioventricular Valve Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Transcription Involved In Cell Fate Commitment Regulation Of Osteoblast Proliferation Protein Destabilization Negative Regulation Of Steroid Metabolic Process Cellular Response To BMP Stimulus Regulation Of Hormone Biosynthetic Process Forebrain Regionalization Cardiac Epithelial To Mesenchymal Transition Regulation Of Astrocyte Differentiation Regulation Of Odontogenesis
Tagcloud ?		agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	autoradiograms caudate dipped emulsion evenly exhibiting film ganglia globus intense intensely lgp medial nr nr2c nr2d nrs pallidal pallidus putamen regional ribonucleotide slides sparse specialization str striatal subpopulation
Tagcloud (Difference) ?		agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	autoradiograms caudate dipped emulsion evenly exhibiting film ganglia globus intense intensely lgp medial nr nr2c nr2d nrs pallidal pallidus putamen regional ribonucleotide slides sparse specialization str striatal subpopulation
Tagcloud (Intersection) ?