BMP2 and SOSTDC1

Number of citations: 0 (PubMedID 15020244)
Data Source: HPRD (in vivo, in vitro)

		BMP2	SOSTDC1
Name		bone morphogenetic protein 2	sclerostin domain containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cilium Cell Surface BMP Receptor Complex Enzyme Activator Complex	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity Receptor Ligand Activity BMP Receptor Binding	BMP Binding BMP Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Heart Induction Endodermal-mesodermal Cell Signaling Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Negative Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ameloblast Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Astrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Bone Development Positive Regulation Of SMAD Protein Signal Transduction Lung Vasculature Development Mesenchyme Development Muscle Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Positive Regulation Of MiRNA Transcription Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cardiac Muscle Cell Differentiation	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Canonical Wnt Signaling Pathway Mammary Gland Bud Morphogenesis Epithelial Cell Fate Commitment Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Determination Of Dorsal Identity
Pathways		Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity	None
GWAS		Adult body size ( 32376654 ) Atrial fibrillation ( 29892015 ) Axial length ( 24144296 ) Body mass index ( 19079261 25673413 23669352 28892062 ) Body size at age 10 ( 32376654 ) Childhood ear infection ( 27182965 ) Colorectal cancer ( 23266556 29471430 24737748 30529582 31826910 25990418 26151821 ) Colorectal cancer or advanced adenoma ( 30510241 ) Copper levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) FEV1 ( 30804560 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 31562340 25429064 25282103 23563607 18391951 20881960 ) Hip circumference adjusted for BMI ( 25673412 ) Lung function (FVC) ( 30804560 28166213 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Major depressive disorder (stressful life events interaction) ( 26845276 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Nose morphology (partial least square model) ( 30174134 ) Obesity-related traits ( 23251661 ) Optic cup area ( 25631615 31798171 28073927 ) Peak expiratory flow ( 30804560 ) Pulse pressure ( 30224653 ) QRS complex (Cornell) ( 27659466 ) Refractive error ( 23396134 32231278 ) Retinal detachment or retinal break ( 31816047 ) Sagittal craniosynostosis ( 23160099 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels x loop diuretics use interaction ( 31806883 ) Vertical cup-disc ratio ( 28073927 25241763 31798171 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 28448500 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 )	Response to statin therapy ( 20339536 )
Interacting Genes		21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2	5 interacting genes: BMP2 BMP4 BMP6 BMP7 CDC20
Entrez ID		650	25928
HPRD ID		00206	15417
Ensembl ID		ENSG00000125845	ENSG00000171243
Uniprot IDs		C8C060 P12643	A4D125 Q6X4U4
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN 7AG0 8E3G	Not available
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Binding Regulation Of SMAD Protein Signal Transduction BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To BMP Stimulus Pattern Specification Process Regulation Of Ossification Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Osteoblast Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Regulation Of BMP Signaling Pathway System Development Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Animal Organ Morphogenesis Tissue Development Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Embryonic Morphogenesis Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Animal Organ Development Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Differentiation Outflow Tract Septum Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Activin Receptor Signaling Pathway Regulation Of Developmental Process Cardiac Septum Morphogenesis Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Developmental Process Activin Binding Pharyngeal Arch Artery Morphogenesis Ventricular Septum Morphogenesis Activin Receptor Activity, Type II	BMP Receptor Binding Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Ameloblast Differentiation Positive Regulation Of Epithelial Cell Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Neuron Differentiation Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Osteoblast Differentiation Ossification Regulation Of Osteoblast Differentiation Growth Factor Activity Regulation Of Epithelial Cell Differentiation Regulation Of Animal Organ Formation Positive Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Skeletal System Development Regulation Of Neuron Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokine Activity Negative Regulation Of Mitotic Nuclear Division Enzyme Activator Complex Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Heart Development Cellular Response To Growth Factor Stimulus Mesenchyme Development Cardiac Jelly Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Prostatic Bud Formation Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Odontogenesis Of Dentin-containing Tooth Bone Development Protein Serine/threonine Kinase Activator Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Cartilage Development System Development Negative Regulation Of Cell Cycle Regulation Of Animal Organ Morphogenesis