BMP2 and BMPER

Number of citations of the paper that reports this interaction (PMID 12897139)
42

Data Source:
HPRD (in vivo)

		BMP2	BMPER
Gene Name		bone morphogenetic protein 2	BMP binding endothelial regulator
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Extracellular Space
	Molecular Function	Retinol Dehydrogenase Activity Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Phosphatase Activator Activity SMAD Binding Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Proliferation Embryo Development Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	Ureteric Bud Development Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Endothelial Cell Migration Negative Regulation Of BMP Signaling Pathway Endothelial Cell Activation Endothelial Cell Differentiation Inner Ear Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Molecules associated with elastic fibres Elastic fibre formation Signaling by BMP
Drugs
Diseases
GWAS		Body mass index ( 19079261 23669352) Colorectal cancer ( 23266556) Height ( 20881960 23563607 18391951) Obesity-related traits ( 23251661) Refractive error ( 23396134) Sagittal craniosynostosis ( 23160099)
Protein-Protein Interactions		19 interactors: ACTR2 ACVR1 ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG SOSTDC1 TGFB1 TGFB2	3 interactors: BMP2 BMP4 BMP6
Entrez ID		650	168667
HPRD ID		00206	16368
Ensembl ID		ENSG00000125845	ENSG00000164619
Uniprot IDs		C8C060 P12643	Q8N8U9
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP
Enriched GO Terms of Interacting Partners?		Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification BMP Signaling Pathway Regulation Of BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Pattern Specification Process Tube Development Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Skeletal System Development Epithelium Development Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Regulation Of Signal Transduction Organ Morphogenesis Multicellular Organismal Development Organ Development Connective Tissue Development Anatomical Structure Development Regulation Of Signaling System Development Positive Regulation Of Bone Mineralization Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Developmental Process Dorsal/ventral Pattern Formation Regulation Of Osteoblast Differentiation Embryonic Morphogenesis Tissue Morphogenesis Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cartilage Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Embryo Development Negative Regulation Of Signaling Regulation Of Cell Differentiation Sensory Organ Development Positive Regulation Of Signal Transduction Mesoderm Development Cell Development Signal Transduction By Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Stem Cell Differentiation	Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Glandular Epithelial Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Endothelial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of Endothelial Cell Proliferation Regulation Of Cartilage Development Positive Regulation Of Ossification BMP Signaling Pathway Involved In Heart Development Regulation Of Osteoblast Differentiation Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Regulation Of Ossification Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Bone Development Regulation Of Odontogenesis Of Dentin-containing Tooth Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Positive Regulation Of Endothelial Cell Differentiation Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Type B Pancreatic Cell Development Ossification Regulation Of Endothelial Cell Differentiation Regulation Of Epithelial Cell Proliferation Kidney Development Regulation Of Transcription Involved In Cell Fate Commitment Type B Pancreatic Cell Differentiation Positive Regulation Of Neuron Differentiation Renal System Development Enteroendocrine Cell Differentiation Forebrain Regionalization Regulation Of Hormone Biosynthetic Process Regulation Of Odontogenesis Urogenital System Development Glandular Epithelial Cell Development Regulation Of Heart Morphogenesis Positive Regulation Of Neurogenesis Regulation Of Hormone Metabolic Process Organ Induction
Tagcloud ?		agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	acts array biology bmp4 coreceptor endocytic endocytosis enhances evidenced fine introduce ldl lrp1 mediate member modulates modulators morphogenetic observations rationale regulator sink smad1 spatial tune unlike vasculogenic zebrafish
Tagcloud (Difference) ?		agonists antagonists apoptosis causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	acts array biology coreceptor endocytic endocytosis enhances evidenced fine introduce ldl lrp1 mediate member modulates modulators morphogenetic observations rationale regulator sink smad1 spatial tune unlike vasculogenic zebrafish
Tagcloud (Intersection) ?		bmp4