BMP2 and GREM1

Number of citations of the paper that reports this interaction (PMID 15064755)
34

Data Source:
HPRD (in vitro)

		BMP2	GREM1
Gene Name		bone morphogenetic protein 2	gremlin 1, DAN family BMP antagonist
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Extracellular Space Cell Surface
	Molecular Function	Retinol Dehydrogenase Activity Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Phosphatase Activator Activity SMAD Binding Protein Heterodimerization Activity BMP Receptor Binding	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Agonist Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Proliferation Embryo Development Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Proliferation Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Signaling by BMP
Drugs
Diseases
GWAS		Body mass index ( 19079261 23669352) Colorectal cancer ( 23266556) Height ( 20881960 23563607 18391951) Obesity-related traits ( 23251661) Refractive error ( 23396134) Sagittal craniosynostosis ( 23160099)	Colorectal cancer ( 21761138 23266556) Orofacial clefts ( 20023658)
Protein-Protein Interactions		19 interactors: ACTR2 ACVR1 ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG SOSTDC1 TGFB1 TGFB2	2 interactors: BMP2 YWHAH
Entrez ID		650	26585
HPRD ID		00206	07048
Ensembl ID		ENSG00000125845	ENSG00000166923
Uniprot IDs		C8C060 P12643	A6XAA7 B3KTR9 O60565
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP
Enriched GO Terms of Interacting Partners?		Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification BMP Signaling Pathway Regulation Of BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Development Pattern Specification Process Tube Development Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Skeletal System Development Epithelium Development Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Regulation Of Signal Transduction Organ Morphogenesis Multicellular Organismal Development Organ Development Connective Tissue Development Anatomical Structure Development Regulation Of Signaling System Development Positive Regulation Of Bone Mineralization Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Developmental Process Dorsal/ventral Pattern Formation Regulation Of Osteoblast Differentiation Embryonic Morphogenesis Tissue Morphogenesis Skeletal System Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cartilage Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Embryo Development Negative Regulation Of Signaling Regulation Of Cell Differentiation Sensory Organ Development Positive Regulation Of Signal Transduction Mesoderm Development Cell Development Signal Transduction By Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Stem Cell Differentiation	Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Negative Regulation Of Calcium-independent Cell-cell Adhesion Glucocorticoid Catabolic Process Corticotropin Hormone Secreting Cell Differentiation BMP Signaling Pathway Involved In Heart Induction Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Aldosterone Biosynthetic Process BMP Signaling Pathway Involved In Heart Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Regulation Of Cell Morphogenesis Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Bone Mineralization Involved In Bone Maturation Negative Regulation Of Cardiac Muscle Cell Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Neuroendocrine Cell Differentiation Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Death Negative Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Glucocorticoid Biosynthetic Process Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Odontogenesis Regulation Of Neurogenesis Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Cell Differentiation Brain Development Pathway-restricted SMAD Protein Phosphorylation Adenohypophysis Development Head Development Telencephalon Regionalization Cell Proliferation Involved In Kidney Development Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Development Regulation Of Cell Development Ossification Involved In Bone Maturation Regulation Of Odontogenesis Of Dentin-containing Tooth Mesenchymal Cell Proliferation Glucocorticoid Metabolic Process Bone Maturation Negative Regulation Of Striated Muscle Cell Differentiation Atrioventricular Valve Morphogenesis
Tagcloud ?		agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	aire amh articles bmp15 dor epigenetics esr1 etiology expose fertility fmr1 foxl2 fshr gdf9 gpr3 idiopathic igf1 igf2 igf2r lhcgr multifactorial november pathologic premature pubmed reserve seeking translocations wnt4
Tagcloud (Difference) ?		agonists antagonists apoptosis bmp4 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	aire amh articles bmp15 dor epigenetics esr1 etiology expose fertility fmr1 foxl2 fshr gdf9 gpr3 idiopathic igf1 igf2 igf2r lhcgr multifactorial november pathologic premature pubmed reserve seeking translocations wnt4
Tagcloud (Intersection) ?