HCLS1 and FGR

Number of citations of the paper that reports this interaction (PubMedID 10066823)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		HCLS1	FGR
Description		hematopoietic cell-specific Lyn substrate 1	FGR proto-oncogene, Src family tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Aggresome Ruffle Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process	Positive Regulation Of Cytokine Production Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways			FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS			Body mass index ( 28892062) Systolic blood pressure ( 30224653)
Interacting Genes		25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		3059	2268
HPRD ID		03199	01288
Ensembl ID		ENSG00000180353	ENSG00000000938
Uniprot IDs		E7EVW7 P14317	P09769 P78453
PDB IDs			7JT9 7UY0 7UY3
Enriched GO Terms of Interacting Partners?		B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization	Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death SH2 Domain Binding Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Immune System Process Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Activity Negative Regulation Of Apoptotic Process
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