HCLS1 and MAP4K1

Number of citations of the paper that reports this interaction (PMID 10233887)
5

Data Source:
HPRD (in vivo)

		HCLS1	MAP4K1
Gene Name		hematopoietic cell-specific Lyn substrate 1	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Membrane	Cytoplasm Membrane
	Molecular Function	RNA Polymerase II Transcription Factor Binding Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Complex Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPKKK Activity Protein Phosphorylation Response To Stress Activation Of JUN Kinase Activity Cell Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	20 interactors: ABL1 BLNK CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		3059	11184
HPRD ID		03199	03583
Ensembl ID		ENSG00000180353	ENSG00000104814
Uniprot IDs		E7EVW7 P14317	Q92918
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Immune System Process Positive Regulation Of Organelle Organization Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Mast Cell Degranulation Meiotic Chromosome Movement Towards Spindle Pole Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Polymerization B Cell Homeostasis Regulation Of Mast Cell Activation Regulation Of Cytoskeleton Organization Regulation Of Regulated Secretory Pathway Regulation Of Cellular Process B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Developmental Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Asymmetric Cell Division Immune Response Regulation Of Organelle Organization Regulation Of Phosphorylation Chemotaxis Defense Response Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Response To External Stimulus	Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Immune System Process Regulation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of MAPK Cascade Regulation Of Immune Response Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Activation Immune Response Positive Regulation Of Protein Phosphorylation Defense Response Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Kinase Activity Platelet Activation Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process MAPK Cascade Cell Surface Receptor Signaling Pathway
Tagcloud ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Intersection) ?