HCLS1 and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 10233887)
0

Data Source:
HPRD (in vivo)

		HCLS1	MAP4K1
Description		hematopoietic cell-specific Lyn substrate 1	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle	Cytoplasm Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132)
Interacting Genes		25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	24 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 PPP2CA SHC1 STRN4 SYK TMEM101
Entrez ID		3059	11184
HPRD ID		03199	03583
Ensembl ID		ENSG00000180353	ENSG00000104814
Uniprot IDs		E7EVW7 P14317	Q92918
PDB IDs			6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC 7L24 7L25 7L26 7M0K 7M0L 7M0M 7R9L 7R9N 7R9P 7R9T 7SIU 8CDW 8CIJ 8EEC 8FH4 8FJZ 8FKO 8PAR 8PAS 8PAU 8XN7 9BI8 9BIK 9BJ1 9CZT 9CZU 9CZW 9CZX 9D00 9H8D 9H8E 9H8F
Enriched GO Terms of Interacting Partners?		B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization	Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Ephrin Receptor Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Signal Transduction Positive Regulation Of Immune Response Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Immune System Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Receptor Tyrosine Kinase Binding Lymphocyte Homeostasis Leukocyte Activation Regulation Of T Cell Activation Leukocyte Homeostasis Lymphocyte Activation Cell Activation Positive Regulation Of Cell Population Proliferation Homeostasis Of Number Of Cells Cytosol Positive Regulation Of Cell Adhesion SH2 Domain Binding Regulation Of Lymphocyte Activation Protein Domain Specific Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?