HCLS1 and BLZF1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HCLS1	BLZF1
Gene Name		hematopoietic cell-specific Lyn substrate 1	basic leucine zipper nuclear factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Lumen
	Molecular Function	RNA Polymerase II Transcription Factor Binding Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Complex Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Enzyme Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	Mitotic Cell Cycle Regulation Of Cell Growth Regulation Of Transcription From RNA Polymerase II Promoter Golgi Organization Cell Proliferation Golgi To Plasma Membrane Protein Transport
Pathways			Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	45 interactors: AKAP9 AMOTL2 BCL6 BEX2 CARD9 CCDC33 CHCHD3 CINP EWSR1 FBF1 FHL2 FRMD6 GEM GORASP2 HCLS1 HOXA1 IQUB KDM1A KLHL38 LMO1 LMO2 OAZ3 PRKAB2 PRMT6 PSMA1 RAB2A RAB2B RAB39A RANBP3 RHOJ SCNM1 SMAD3 SRA1 SSX2 SUV39H2 TBC1D7 TRAPPC2L TSC22D4 TXNDC5 VPS28 ZBTB24 ZGPAT ZMAT1 ZNF410 ZZZ3
Entrez ID		3059	8548
HPRD ID		03199	16367
Ensembl ID		ENSG00000180353	ENSG00000117475
Uniprot IDs		E7EVW7 P14317	Q9H2G9
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Immune System Process Positive Regulation Of Organelle Organization Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Mast Cell Degranulation Meiotic Chromosome Movement Towards Spindle Pole Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Polymerization B Cell Homeostasis Regulation Of Mast Cell Activation Regulation Of Cytoskeleton Organization Regulation Of Regulated Secretory Pathway Regulation Of Cellular Process B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Developmental Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Asymmetric Cell Division Immune Response Regulation Of Organelle Organization Regulation Of Phosphorylation Chemotaxis Defense Response Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Response To External Stimulus	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Ras Protein Signal Transduction Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Organelle Organization Rab Protein Signal Transduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Cellular Amino Acid Metabolic Process Small GTPase Mediated Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Intracellular Transport Positive Regulation Of Cellular Metabolic Process Immune System Development Negative Regulation Of Cell Death Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Stimulus Establishment Of Localization In Cell Regulation Of Erythrocyte Differentiation
Tagcloud ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?