HCLS1 and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HCLS1	LZTR1
Description		hematopoietic cell-specific Lyn substrate 1	leucine zipper like post translational regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Interacting Genes		25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		3059	8216
HPRD ID		03199	08992
Ensembl ID		ENSG00000180353	ENSG00000099949
Uniprot IDs		E7EVW7 P14317	A0A384NL67 Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?		B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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