HCLS1 and CD79A

Number of citations of the paper that reports this interaction (PMID 7927516)
2

Data Source:
HPRD (in vivo)

		HCLS1	CD79A
Gene Name		hematopoietic cell-specific Lyn substrate 1	CD79a molecule, immunoglobulin-associated alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Membrane	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft
	Molecular Function	RNA Polymerase II Transcription Factor Binding Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Complex Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	17 interactors: BLK BLNK CD19 CD5 CD79B FANCA FATE1 FCAR FYN HCLS1 IGHM IGJ LCK LYN PIGR PTPN6 SYK
Entrez ID		3059	973
HPRD ID		03199	00203
Ensembl ID		ENSG00000180353	ENSG00000105369
Uniprot IDs		E7EVW7 P14317	P11912
PDB IDs			1CV9
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Innate Immune Response Immune System Process Positive Regulation Of Organelle Organization Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Mast Cell Degranulation Meiotic Chromosome Movement Towards Spindle Pole Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Polymerization B Cell Homeostasis Regulation Of Mast Cell Activation Regulation Of Cytoskeleton Organization Regulation Of Regulated Secretory Pathway Regulation Of Cellular Process B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Developmental Process Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Asymmetric Cell Division Immune Response Regulation Of Organelle Organization Regulation Of Phosphorylation Chemotaxis Defense Response Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Response To External Stimulus	B Cell Receptor Signaling Pathway Immune System Process Antigen Receptor-mediated Signaling Pathway Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune System Process Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Defense Response Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Stimulus Hemopoiesis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Activation Regulation Of Lymphocyte Activation Platelet Activation Immune System Development Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Activation Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Response To Stress Cellular Response To Peptide Homotypic Cell-cell Adhesion Regulation Of Cell Proliferation Regulation Of Cell Adhesion Leukocyte Differentiation Regulation Of Cellular Localization Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Tagcloud ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	abdomen axillae bence cd138 cd20 cd56 dermis disappearing emp enlarged extramedullar fig immunohistological inguinal jones microglobulin monotypic painless pcp pcps plasmacytoid plasmacytoma pointed reappeared runs subcutis temporarily vincristine
Tagcloud (Difference) ?		actn1 candidates clonogenic gap gy integration integrin itgb5 junction junctions microarray microarrays nci overrepresented pfn2 platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature	abdomen axillae bence cd138 cd20 cd56 dermis disappearing emp enlarged extramedullar fig immunohistological inguinal jones microglobulin monotypic painless pcp pcps plasmacytoid plasmacytoma pointed reappeared runs subcutis temporarily vincristine
Tagcloud (Intersection) ?