OCLN and TJP2

Number of citations of the paper that reports this interaction (PMID 10575001)
84

Data Source:
BioGRID (pull down)

		OCLN	TJP2
Gene Name		occludin	tight junction protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Tight Junction Cell Junction
	Molecular Function	Structural Molecule Activity Protein Binding Thiopurine S-methyltransferase Activity Protein Domain Specific Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging
	Biological Process	Protein Complex Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Methylation Cell-cell Junction Organization S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Tight Junction Assembly	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Organic Substance Hippo Signaling Nucleotide Phosphorylation Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability
Pathways		Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase	Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Signaling by Hippo Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Refractive error ( 23396134) Renal sinus fat ( 22044751)
Protein-Protein Interactions		4 interactors: CLEC7A SYNE4 TJP2 TNFAIP3	15 interactors: CDK6 CGN CLDN1 CLDN2 CTNNA1 EPB41 HGS OCLN SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		100506658	9414
HPRD ID			06369
Ensembl ID		ENSG00000197822	ENSG00000119139
Uniprot IDs		A8K3T2 Q16625	B7Z2R3 B7Z954 Q9UDY2
PDB IDs		1WPA 1XAW 3G7C	2OSG 3E17
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of CD40 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Tolerance Induction To Lipopolysaccharide Positive Regulation Of Innate Immune Response Carbohydrate Mediated Signaling Regulation Of CD40 Signaling Pathway Regulation Of Vascular Wound Healing Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Chronic Inflammatory Response Regulation Of Innate Immune Response Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway B-1 B Cell Homeostasis Establishment Of Endothelial Intestinal Barrier Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Regulation Of Hepatocyte Proliferation Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Of Monopolar Cell Polarity Regulation Of Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Bone Resorption Negative Regulation Of Interleukin-1 Beta Production Regulation Of Germinal Center Formation Immune Response-regulating Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Response To Muramyl Dipeptide Protein K48-linked Deubiquitination Phagocytosis, Recognition Protein K63-linked Deubiquitination Establishment Of Epithelial Cell Polarity Epithelial Cell Differentiation Negative Regulation Of Interleukin-2 Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Of Protein Localization To Vacuole Defense Response To Protozoan	Cell-cell Junction Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell-cell Junction Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Cell Junction Assembly Positive Regulation Of Apoptotic Signaling Pathway Apical Junction Assembly Positive Regulation Of Mitochondrion Organization Epithelial Cell Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Mitochondrion Organization Signaling Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Communication Protein Targeting Membrane Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hippo Signaling Enzyme Linked Receptor Protein Signaling Pathway Intrinsic Apoptotic Signaling Pathway Signal Transduction Epithelial Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tight Junction Assembly Positive Regulation Of Intracellular Transport Negative Regulation Of ERBB Signaling Pathway Cell Development Cell Adhesion Cellular Component Assembly Protein Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Cell Dedifferentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signal Transduction Positive Regulation Of Transport Cellular Protein Localization Execution Phase Of Apoptosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Integrin-mediated Signaling Pathway
Tagcloud ?		accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Difference) ?		accordingly ap4 besides bioinformatic cadherin cd44 cdh1 claudins concomitantly conversely crc displays ectopic emt fn1 helix hundreds imply invasion lgr5 mesenchymal myc presumably repressed snail stemness tfap4 transition vim
Tagcloud (Intersection) ?