SH2B3 and CD247

Number of citations of the paper that reports this interaction (PMID 10799879)
17

Data Source:
HPRD (in vivo)

		SH2B3	CD247
Gene Name		SH2B adaptor protein 3	CD247 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Signal Transducer Activity Protein Binding Protein Complex Binding Phosphate Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Blood Coagulation Cell Differentiation Embryonic Hemopoiesis Intracellular Signal Transduction	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta-2 microglubulin plasma levels ( 23417110) Celiac disease ( 20190752 18311140) Celiac disease and Rheumatoid arthritis ( 21383967) Coronary heart disease ( 21378990) Diastolic blood pressure ( 19430479 19430483 21909115) Eosinophil counts ( 19198610) Hematocrit ( 19862010) Hypothyroidism ( 22493691) Platelet counts ( 22139419 20139978) Red blood cell traits ( 23222517) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 20453842) Systolic blood pressure ( 19430479) Type 1 diabetes ( 19430480 17554300) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)	Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		9 interactors: CD247 EGFR ERBB2 ERBB3 FLNA GRB2 KIT LCK ZAP70	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		10019	919
HPRD ID		05480	01729
Ensembl ID		ENSG00000111252	ENSG00000198821
Uniprot IDs		F5GYM4 Q59H48 Q9UQQ2	P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Adhesion Response To Stress Regulation Of T Cell Activation Immune System Process Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Signal Transduction Peptidyl-amino Acid Modification Regulation Of Cell Activation Organ Development Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Wound Healing Positive Regulation Of Cell-cell Adhesion Signal Transduction Cell Differentiation	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		aggregated aggregately ancestry atp2b1 bp cacnb2 conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp snp strongest	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		aggregated aggregately ancestry atp2b1 bp cacnb2 conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp snp strongest	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?