SH2B3

Gene Name		SH2B adaptor protein 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Signal Transducer Activity Protein Binding Protein Complex Binding Phosphate Ion Binding
	Biological Process	Blood Coagulation Cell Differentiation Embryonic Hemopoiesis Intracellular Signal Transduction
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Beta-2 microglubulin plasma levels ( 23417110) Celiac disease ( 20190752 18311140) Celiac disease and Rheumatoid arthritis ( 21383967) Coronary heart disease ( 21378990) Diastolic blood pressure ( 19430479 19430483 21909115) Eosinophil counts ( 19198610) Hematocrit ( 19862010) Hypothyroidism ( 22493691) Platelet counts ( 22139419 20139978) Red blood cell traits ( 23222517) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 20453842) Systolic blood pressure ( 19430479) Type 1 diabetes ( 19430480 17554300) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)
Protein-protein Interactions		9 interactors: CD247 EGFR ERBB2 ERBB3 FLNA GRB2 KIT LCK ZAP70
Entrez ID		10019
HPRD ID		05480
Ensembl ID		ENSG00000111252
Uniprot IDs		F5GYM4 Q59H48 Q9UQQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Adhesion Response To Stress Regulation Of T Cell Activation Immune System Process Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Signal Transduction Peptidyl-amino Acid Modification Regulation Of Cell Activation Organ Development Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Wound Healing Positive Regulation Of Cell-cell Adhesion Signal Transduction Cell Differentiation
Tagcloud ?		aggregated aggregately ancestry atp2b1 bp cacnb2 conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp snp strongest