SH2B3 and KIT

Number of citations of the paper that reports this interaction (PMID 11805142)
34

Data Source:
HPRD (in vitro)

		SH2B3	KIT
Gene Name		SH2B adaptor protein 3	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Acrosomal Vesicle Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Mast Cell Granule
	Molecular Function	Signal Transducer Activity Protein Binding Protein Complex Binding Phosphate Ion Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Blood Coagulation Cell Differentiation Embryonic Hemopoiesis Intracellular Signal Transduction	Activation Of MAPK Activity Ovarian Follicle Development Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Maintenance Signal Transduction By Phosphorylation Lamellipodium Assembly Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Somatic Stem Cell Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Megakaryocyte Development Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Developmental Pigmentation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Beta-2 microglubulin plasma levels ( 23417110) Celiac disease ( 20190752 18311140) Celiac disease and Rheumatoid arthritis ( 21383967) Coronary heart disease ( 21378990) Diastolic blood pressure ( 19430479 19430483 21909115) Eosinophil counts ( 19198610) Hematocrit ( 19862010) Hypothyroidism ( 22493691) Platelet counts ( 22139419 20139978) Red blood cell traits ( 23222517) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 20453842) Systolic blood pressure ( 19430479) Type 1 diabetes ( 19430480 17554300) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)	Bipolar disorder ( 19416921) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		9 interactors: CD247 EGFR ERBB2 ERBB3 FLNA GRB2 KIT LCK ZAP70	56 interactors: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B TEC YES1
Entrez ID		10019	3815
HPRD ID		05480	01287
Ensembl ID		ENSG00000111252	ENSG00000157404
Uniprot IDs		F5GYM4 Q59H48 Q9UQQ2	P10721
PDB IDs			1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Adhesion Response To Stress Regulation Of T Cell Activation Immune System Process Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Signal Transduction Peptidyl-amino Acid Modification Regulation Of Cell Activation Organ Development Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Wound Healing Positive Regulation Of Cell-cell Adhesion Signal Transduction Cell Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Immune Response Regulation Of Immune System Process Response To Peptide Hormone Positive Regulation Of Immune System Process Signal Transduction Cellular Response To Organonitrogen Compound Intracellular Signal Transduction Cellular Response To Organic Substance Response To Peptide Regulation Of Body Fluid Levels Response To Organic Substance Immune System Process Signaling Regulation Of Cell Activation Cell Communication Cellular Response To Hormone Stimulus Blood Coagulation Hemostasis Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Signaling Innate Immune Response Regulation Of Cell Adhesion Response To Organonitrogen Compound Regulation Of Lymphocyte Activation Response To Hormone Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Leukocyte Migration Immune Response Response To Wounding Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation
Tagcloud ?		aggregated aggregately ancestry atp2b1 bp cacnb2 conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp snp strongest	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Difference) ?		aggregated aggregately ancestry atp2b1 bp cacnb2 conditioning consortium cyp17a1 dbp epidemiology gwas harbor individually intronic jag1 ld maf plekha7 pp rs11191416 rs112467382 rs12806040 rs1571787 rs6163 rs743572 sbp snp strongest	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Intersection) ?