CPNE4 and SKIL

Number of citations of the paper that reports this interaction (PubMedID 12522145)
0

Data Source:
HPRD (two hybrid, in vitro)

		CPNE4	SKIL
Description		copine 4	SKI like proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synapse Extracellular Exosome Glutamatergic Synapse	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Protein-containing Complex
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding SMAD Binding
	Biological Process	Cellular Response To Calcium Ion	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Response To Antibiotic Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Muscle Structure Development Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis ( 22959728) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Body mass index ( 25673413 28892062 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Circulating leptin levels in high cardiovascular risk ( 31766143) Coronary artery aneurysm in Kawasaki disease ( 27171184) Eosinophilic esophagitis ( 34506852) HDL cholesterol levels ( 32203549) Intracranial aneurysm ( 29531279) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Metabolic syndrome ( 31589552) Motion sickness ( 25628336) Neutrophil count ( 21507922) Retinitis pigmentosa ( 33514863)	Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		17 interacting genes: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP NECAB1 PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O	97 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRC4 DRG1 DSCAM EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		131034	6498
HPRD ID		05017	01319
Ensembl ID		ENSG00000196353	ENSG00000136603
Uniprot IDs		B7Z370 Q4G168 Q96A23	P12757
PDB IDs			3EQ5 5C4V
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Cortical Cytoskeleton Nucleoplasm Cytoplasm Apical Protein Localization Structural Constituent Of Cytoskeleton Cytoskeleton Cytosol Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein-containing Complex Binding Regulation Of Intracellular Signal Transduction Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Receptor Localization To Synapse Regulation Of Early Endosome To Late Endosome Transport Actin Filament Capping Blastocyst Hatching Regulation Of Protein Localization To Membrane Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Cell Communication Vesicle-mediated Transport Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Tooth Mineralization BCOR Complex Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Cortical Actin Cytoskeleton Establishment Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Heat Shock Protein Binding Golgi Inheritance Central Nervous System Formation Golgi To Plasma Membrane Transport NEDD8 Conjugating Enzyme Activity Regulation Of Vesicle-mediated Transport Ubiquitin-protein Transferase Activity Glutamatergic Synapse Nucleus Transporter Regulator Activity	PML Body Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Heteromeric SMAD Protein Complex SUMO Transferase Activity Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process SUMO Ligase Activity I-SMAD Binding Collagen Binding Regulation Of Macromolecule Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Protein Metabolic Process Metal Ion Binding Protein Modification By Small Protein Conjugation Nuclear Body Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Protein Sumoylation Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Zinc Ion Binding Regulation Of Metabolic Process Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus SUMO Binding Homomeric SMAD Protein Complex Negative Regulation Of Transforming Growth Factor Beta Production Co-SMAD Binding Regulation Of Gene Expression Regulation Of Developmental Process Extracellular Matrix Structural Constituent Primary MiRNA Processing Positive Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytosol
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