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CPNE4 and UBE2M
Number of citations of the paper that reports this interaction (PMID
12522145
)
20
Data Source:
HPRD
(in vitro)
CPNE4
UBE2M
Gene Name
copine IV
ubiquitin-conjugating enzyme E2M
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Vesicular Exosome
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ribosomal S6-glutamic Acid Ligase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Cellular Protein Modification Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Ubiquitination
Positive Regulation Of Neuron Apoptotic Process
Protein Neddylation
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (
22959728
)
Neutrophil count (
21507922
)
Protein-Protein Interactions
16 interactors:
ACTB
BCOR
BICD1
CCDC22
CEP162
CPNE1
MAP2K1
MYCBP
PDCD6
PITPNM2
PPP5C
RDX
SKIL
SPTBN1
UBE2M
UBE2O
24 interactors:
APP
CAND1
CBL
CPNE1
CPNE2
CPNE4
CUL1
CUL3
CUL7
DCUN1D3
DCUN1D4
MARCH7
MDM2
NAE1
NEDD4
NEDD8
PARK2
PINK1
RBX1
RNF111
RNF7
TP53
UBA3
UBC
Entrez ID
131034
9040
HPRD ID
05017
04414
Ensembl ID
ENSG00000196353
ENSG00000130725
Uniprot IDs
Q96A23
P61081
PDB IDs
1TT5
1Y8X
2NVU
3TDU
3TDZ
4GAO
Enriched GO Terms of Interacting Partners
?
Cellular Component Assembly
Enzyme Linked Receptor Protein Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Protein Heterooligomerization
Golgi To Plasma Membrane Transport
Intracellular Transport
Protein Monoubiquitination
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Actin Filament Capping
Organelle Transport Along Microtubule
Cell Projection Organization
Regulation Of Proteinase Activated Receptor Activity
Negative Regulation Of Histone H3-K36 Methylation
Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Actin Filament Polymerization
Regulation Of Signal Transduction
Establishment Of Localization In Cell
Negative Regulation Of Tooth Mineralization
Negative Regulation Of Phospholipase C Activity
Negative Regulation Of Protein Polymerization
Post-Golgi Vesicle-mediated Transport
Positive Regulation Of Intracellular Signal Transduction
Anatomical Structure Development
Negative Regulation Of Protein Complex Disassembly
Transport
Cell Projection Morphogenesis
Vesicle-mediated Transport
Minus-end-directed Organelle Transport Along Microtubule
Axon Guidance
Cell Part Morphogenesis
Regulation Of Signaling
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Protein Depolymerization
Regulation Of Organelle Organization
Regulation Of Golgi Inheritance
Protein Oligomerization
Regulation Of Protein Complex Disassembly
Specification Of Axis Polarity
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Cellular Localization
Negative Regulation Of Protein Complex Assembly
Microtubule-based Transport
Regulation Of Vascular Smooth Muscle Contraction
Common-partner SMAD Protein Phosphorylation
Negative Regulation Of Odontogenesis
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Neddylation
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Modification Process
Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Protein Metabolic Process
Protein Monoubiquitination
Proteolysis
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Hypoxia
Regulation Of Mitochondrion Degradation
Cellular Response To Decreased Oxygen Levels
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Catabolic Process
Regulation Of Cell Cycle Phase Transition
Cellular Response To Oxygen Levels
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Positive Regulation Of Protein Ubiquitination
Catabolic Process
Notch Signaling Pathway
Regulation Of Cell Cycle Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Catabolic Process
Viral Process
Protein Polyubiquitination
Negative Regulation Of Signaling
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Catabolic Process
Apoptotic Process
Cellular Response To Toxic Substance
Regulation Of Proteolysis
Positive Regulation Of Cell Cycle Process
Signaling
Mitotic Cell Cycle Process
Response To Oxidative Stress
Tagcloud
?
acts
affects
balance
brca1
breaks
choice
controller
controlling
ctip
cytotoxic
deneddylation
great
homologous
indeed
neddylation
nhej
recombination
repair
repaired
resection
respond
rnf111
ssdna
strand
subpathways
tight
toward
uncover
way
Tagcloud (Difference)
?
acts
affects
balance
brca1
breaks
choice
controller
controlling
ctip
cytotoxic
deneddylation
great
homologous
indeed
neddylation
nhej
recombination
repair
repaired
resection
respond
rnf111
ssdna
strand
subpathways
tight
toward
uncover
way
Tagcloud (Intersection)
?