TANK and CEP63

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TANK	CEP63
Gene Name		TRAF family member-associated NFKB activator	centrosomal protein 63kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Dietary macronutrient intake ( 23372041) Educational attainment ( 23722424) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Subcutaneous adipose tissue ( 22589738) Treatment response for severe sepsis ( 22310353)	Height ( 18391952)
Protein-Protein Interactions		31 interactors: AIMP2 APBA3 APP ATP6V1H BIK CEP63 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCH5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRIM37 USP7 ZC3H12A	44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10
Entrez ID		10010	80254
HPRD ID		04870	07826
Ensembl ID		ENSG00000136560	ENSG00000182923
Uniprot IDs		B2R7S3 Q6NW12 Q92844	Q96MT8
PDB IDs		1KZZ 1L0A
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Apoptotic Process Viral Process Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Cellular Response To Tumor Necrosis Factor Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Innate Immune Response Response To Tumor Necrosis Factor Cellular Response To Stimulus I-kappaB Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cell Communication Signal Transduction Regulation Of Cellular Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Metabolic Process	Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process
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